Kutluturk, Isil; Agarwal, Aniruddha; Shulman, Shiri; Vitale, Albert; Parodi, Maurizio B; Conrady, Christoph D; Hurtikova, Katarina; Cunha Souza, Eduardo; Rodriguez, Ever Caso; Chhablani, Jay; Tappeiner, Christoph; Gerding, Heinrich; Zinkernagel, Martin S.; Tucker, William; Munk, Marion R. (2021). The Clinical Characteristics of Unilateral Placoid Pigment Epitheliopathies. Ocular immunology and inflammation, 29(6), pp. 1072-1079. Taylor & Francis 10.1080/09273948.2019.1705498
Full text not available from this repository. (Request a copy)Purpose: Placoid-pigment-epitheliopathies like Acute-Posterior-Multifocal-Placoid-Pigment Epitheliopathy (APMPPE) and Relentless-Placoid-Choroidopathy (RPC) usually show bilateral involvement. This retrospective case series describes the clinical features with unilateral disease onset.Methods: 21 patients from 9 tertiary referring institutions were collected and evaluated.Results: Seventeen patients were included: 11 (65%) had unilateral placoid-pigment-epitheliopathy consistent with APMPPE, 6 (35%) with RPC (mean age: 28.82 ± 9.1 years). Mean follow-up time was 45 ± 48 months. Forty-one percent fellow-eyes had initial inflammatory signs including vitreous-cells, vascular-sheathing, and ONH swelling. Thirty-five percent developed chorioretinal lesions during follow-up after 19.5 ± 16.9 months. Initial inflammation in fellow-eye was not associated with fellow-eye involvement (p = .5). However, subfoveal choroidal-thickness (SCT) at baseline was significantly thicker in fellow-eyes who developed chorioretinal lesion compared to fellow-eyes who did not (400 ± 70 µm versus 283 ± 127 µm,p = .047).Conclusion: Unaffected fellow-eyes may have inflammatory signs at initial disease-onset and may develop lesions over time. They should be carefully monitored, particularly if they present with an increased SCT.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology |
UniBE Contributor: |
Tappeiner, Christoph, Zinkernagel, Martin Sebastian, Munk, Marion |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1744-5078 |
Publisher: |
Taylor & Francis |
Language: |
English |
Submitter: |
Marion Munk |
Date Deposited: |
16 Mar 2020 14:13 |
Last Modified: |
02 Mar 2023 23:33 |
Publisher DOI: |
10.1080/09273948.2019.1705498 |
PubMed ID: |
32077774 |
Uncontrolled Keywords: |
Choroiditis choroidopathy inflammation placoid relentless |
URI: |
https://boris.unibe.ch/id/eprint/141128 |
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