Signalling functions of alpha-tocopherol in smooth muscle cells.

Azzi, A; Boscoboinik, D; Clément, S; Ozer, N K; Ricciarelli, R; Stocker, Achim; Tasinato, A; Sirikçi, O (1997). Signalling functions of alpha-tocopherol in smooth muscle cells. International Journal for Vitamin and Nutrition Research, 67(5), pp. 343-349. Hogrefe

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alpha-Tocopherol but not beta-tocopherol, activates protein phosphatase 2A, decreases protein kinase C activity and attenuates smooth muscle cell proliferation at physiological concentrations. beta-Tocopherol prevents the effects of alpha-tocopherol. Inhibition of protein kinase C alpha, but not of the other isoforms, by the inhibitor Gö6976 prevents the effect of alpha-tocopherol. Protein kinase C alpha, immunoprecipitated from alpha-tocopherol treated cells, is less phosphorylated and inactive. It is proposed that the specific activation of protein phosphatase 2A by alpha-tocopherol results in dephosphorylation and inactivation of protein kinase C alpha. Finally, this cascade of events leads to smooth muscle cell proliferation inhibition.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry

UniBE Contributor:

Stocker, Achim

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry

ISSN:

0300-9831

Publisher:

Hogrefe

Language:

English

Submitter:

Anja Ebeling

Date Deposited:

11 Mar 2020 15:30

Last Modified:

11 Mar 2020 15:30

PubMed ID:

9350476

URI:

https://boris.unibe.ch/id/eprint/141795

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