Signalling functions of alpha-tocopherol in smooth muscle cells.

Azzi, A; Boscoboinik, D; Clément, S; Ozer, N K; Ricciarelli, R; Stocker, Achim; Tasinato, A; Sirikçi, O (1997). Signalling functions of alpha-tocopherol in smooth muscle cells. International Journal for Vitamin and Nutrition Research, 67(5), pp. 343-349. Hogrefe

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alpha-Tocopherol but not beta-tocopherol, activates protein phosphatase 2A, decreases protein kinase C activity and attenuates smooth muscle cell proliferation at physiological concentrations. beta-Tocopherol prevents the effects of alpha-tocopherol. Inhibition of protein kinase C alpha, but not of the other isoforms, by the inhibitor Gö6976 prevents the effect of alpha-tocopherol. Protein kinase C alpha, immunoprecipitated from alpha-tocopherol treated cells, is less phosphorylated and inactive. It is proposed that the specific activation of protein phosphatase 2A by alpha-tocopherol results in dephosphorylation and inactivation of protein kinase C alpha. Finally, this cascade of events leads to smooth muscle cell proliferation inhibition.

Item Type:	Journal Article (Original Article)
Division/Institute:	08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP)
UniBE Contributor:	Stocker, Achim
Subjects:	500 Science > 570 Life sciences; biology 500 Science > 540 Chemistry
ISSN:	0300-9831
Publisher:	Hogrefe
Language:	English
Submitter:	Anja Ebeling
Date Deposited:	11 Mar 2020 15:30
Last Modified:	05 Dec 2022 15:37
PubMed ID:	9350476
URI:	https://boris.unibe.ch/id/eprint/141795