Longitudinal Retinal Layer Changes and Clinical Outcome in Patients with Multiple Evanescent White Dot Syndrome.

Schuerch, Kaspar; Ma, Jeffrey H; Wolf, Sebastian; Ebneter, Andreas; Zinkernagel, Martin S.; Munk, Marion R. (2020). Longitudinal Retinal Layer Changes and Clinical Outcome in Patients with Multiple Evanescent White Dot Syndrome. (In Press). Ocular immunology and inflammation, pp. 1-7. Taylor & Francis 10.1080/09273948.2020.1717545

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Purpose: To evaluate longitudinal changes in retinal layer thickness and clinical outcome in patients with MEWDS.Methods: In 20 patients with MEWDS, SD-OCT images and BCVA were assessed at baseline, and at months 1, 3, and 12. SD-OCTs were segmented and measurements were performed within the fovea and a MEWDS lesion. Baseline and follow-up values in the affected eye were compared to measurements performed at the corresponding location in the fellow eye.Results: ONL thickness was 4.7% thicker in MEWDS-eyes compared with the baseline, with a significant decrease of 9% at 3 months. Within the lesion, INL thickness was 7.9% increased at baseline and decreased significantly over the follow-up of 12 months. BCVA was decreased at baseline (0.2 ± 0.18logMAR) and at the 3 months but after 12 months had increased to 0.01 ± 0.04 logMAR.Conclusion: MEWDS shows the involvement of different retinal layers and characteristic changes over the disease course.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology

UniBE Contributor:

Schürch, Kaspar Werner; Wolf, Sebastian; Ebneter, Andreas; Zinkernagel, Martin and Munk, Marion

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1744-5078

Publisher:

Taylor & Francis

Language:

English

Submitter:

Marion Munk

Date Deposited:

06 Apr 2020 17:53

Last Modified:

06 Apr 2020 17:53

Publisher DOI:

10.1080/09273948.2020.1717545

PubMed ID:

32125930

Uncontrolled Keywords:

MEWDS Multiple evanescent white dot syndrome ganglion cells optical coherence tomography photoreceptors

URI:

https://boris.unibe.ch/id/eprint/141986

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