Echinococcus metacestodes as laboratory models for the screening of drugs against cestodes and trematodes

Hemphill, A.; Stadelmann, B.; Scholl, S.; Muller, J.; Spiliotis, M.; Muller, N.; Gottstein, B.; Siles-Lucas, M. (2010). Echinococcus metacestodes as laboratory models for the screening of drugs against cestodes and trematodes. Parasitology, 137(3), pp. 569-87. London: Cambridge University Press 10.1017/S003118200999117X

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Among the cestodes, Echinococcus granulosus, Echinococcus multilocularis and Taenia solium represent the most dangerous parasites. Their larval stages cause the diseases cystic echinococcosis (CE), alveolar echinococcosis (AE) and cysticercosis, respectively, which exhibit considerable medical and veterinary health concerns with a profound economic impact. Others caused by other cestodes, such as species of the genera Mesocestoides and Hymenolepis, are relatively rare in humans. In this review, we will focus on E. granulosus and E. multilocularis metacestode laboratory models and will review the use of these models in the search for novel drugs that could be employed for chemotherapeutic treatment of echinococcosis. Clearly, improved therapeutic drugs are needed for the treatment of AE and CE, and this can only be achieved through the development of medium-to-high throughput screening approaches. The most recent achievements in the in vitro culture and genetic manipulation of E. multilocularis cells and metacestodes, and the accessability of the E. multilocularis genome and EST sequence information, have rendered the E. multilocularis model uniquely suited for studies on drug-efficacy and drug target identification. This could lead to the development of novel compounds for the use in chemotherapy against echinococcosis, and possibly against diseases caused by other cestodes, and potentially also trematodes.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Parasitology

UniBE Contributor:

Hemphill, Andrew; Müller, Heinz Joachim; Spiliotis, Markus; Müller, Norbert and Gottstein, Bruno

ISSN:

0031-1820

Publisher:

Cambridge University Press

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:36

Last Modified:

23 Jul 2018 11:53

Publisher DOI:

10.1017/S003118200999117X

PubMed ID:

19765346

Web of Science ID:

000276440600018

BORIS DOI:

10.7892/boris.14292

URI:

https://boris.unibe.ch/id/eprint/14292 (FactScience: 221187)

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