Müller, Heinz Joachim

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2024

Müller, Joachim; Hemphill, Andrew (2024). In vitro screening technologies for the discovery and development of novel drugs against Toxoplasma gondii. Expert opinion on drug discovery, 19(1), pp. 97-109. Taylor & Francis 10.1080/17460441.2023.2276349

2023

Schlange, Carling; Müller, Joachim; Imhof, Dennis; Hänggeli, Kai Pascal Alexander; Boubaker, Ghalia; Ortega-Mora, Luis-Miguel; Wong, Ho Ning; Haynes, Richard K; Van Voorhis, Wesley C; Hemphill, Andrew (2023). Single and combination treatment of Toxoplasma gondii infections with a bumped kinase inhibitor and artemisone in vitro and with artemiside in experimentally infected mice. Experimental parasitology, 255(108655), p. 108655. Elsevier 10.1016/j.exppara.2023.108655

Hänggeli, Kai Pascal Alexander; Hemphill, Andrew; Müller, Norbert; Heller, Manfred; Uldry, Anne-Christine; Braga-Lagache, Sophie; Müller, Joachim; Boubaker, Ghalia (2023). Comparative Proteomic Analysis of Toxoplasma gondii RH Wild-Type and Four SRS29B (SAG1) Knock-Out Clones Reveals Significant Differences between Individual Strains. International journal of molecular sciences, 24(13) MDPI 10.3390/ijms241310454

Hemphill, Andrew; Müller, Joachim (2023). Toxoplasma gondii infection: Novel emerging therapeutic targets. Expert opinion on therapeutic targets, 27(4-5), pp. 293-304. Taylor & Francis 10.1080/14728222.2023.2217353

Müller, Joachim; Schlange, Carling; Heller, Manfred; Uldry, Anne-Christine; Braga-Lagache, Sophie; Haynes, Richard K; Hemphill, Andrew (2023). Proteomic characterization of Toxoplasma gondii ME49 derived strains resistant to the artemisinin derivatives artemiside and artemisone implies potential mode of action independent of ROS formation. International journal for parasitology. Drugs and drug resistance, 21, pp. 1-12. Elsevier 10.1016/j.ijpddr.2022.11.005

Memedovski, Roman; Preza, Matías; Müller, Joachim; Kämpfer, Tobias Emmanuel; Rufener, Reto; de Souza, Marcus Vinicius Nora; da Silva, Emerson Teixeira; de Andrade, Gabriel Fernandes; Braga, Sophie; Uldry, Anne-Christine; Buchs, Natasha; Heller, Manfred; Lundström-Stadelmann, Britta (2023). Investigation of the mechanism of action of mefloquine and derivatives against the parasite Echinococcus multilocularis. International journal for parasitology. Drugs and drug resistance, 21, pp. 114-124. Elsevier 10.1016/j.ijpddr.2023.03.002

Müller, Joachim; Preza, Matías; Kaethner, Marc; Rufener, Reto; Braga, Sophie; Uldry, Anne-Christine; Heller, Manfred; Lundström-Stadelmann, Britta (2023). Targeted and non-targeted proteomics to characterize the parasite proteins of Echinococcus multilocularis metacestodes. Frontiers in cellular and infection microbiology, 13, p. 1170763. Frontiers 10.3389/fcimb.2023.1170763

2022

Müller, Joachim; Boubaker, Ghalia; Imhof, Dennis; Hänggeli, Kai; Haudenschild, Noé; Uldry, Anne-Christine; Braga-Lagache, Sophie; Heller, Manfred; Ortega-Mora, Luis-Miguel; Hemphill, Andrew (2022). Differential Affinity Chromatography Coupled to Mass Spectrometry: A Suitable Tool to Identify Common Binding Proteins of a Broad-Range Antimicrobial Peptide Derived from Leucinostatin. Biomedicines, 10(11) MDPI 10.3390/biomedicines10112675

Zheng, Yang; Müller, Joachim; Kunz, Stefan; Siderius, Marco; Maes, Louis; Caljon, Guy; Müller, Norbert; Hemphill, Andrew; Sterk, Geert Jan; Leurs, Rob (2022). 3-nitroimidazo[1,2-b]pyridazine as a novel scaffold for antiparasitics with sub-nanomolar anti-Giardia lamblia activity. International journal for parasitology. Drugs and drug resistance, 19, pp. 47-55. Elsevier 10.1016/j.ijpddr.2022.05.004

Müller, Joachim; Anghel, Nicoleta; Imhof, Dennis; Hänggeli, Kai; Uldry, Anne-Christine; Braga-Lagache, Sophie; Heller, Manfred; Ojo, Kayode K; Ortega-Mora, Luis-Miguel; Van Voorhis, Wesley C; Hemphill, Andrew (2022). Common Molecular Targets of a Quinolone Based Bumped Kinase Inhibitor in Neospora caninum and Danio rerio. International journal of molecular sciences, 23(4) MDPI 10.3390/ijms23042381

Hänggeli, Kai Pascal Alexander; Hemphill, Andrew; Müller, Norbert; Schimanski, Bernd; Olias, Philipp; Müller, Joachim; Boubaker, Ghalia (2022). Single- and duplex TaqMan-quantitative PCR for determining the copy numbers of integrated selection markers during site-specific mutagenesis in Toxoplasma gondii by CRISPR-Cas9. PLoS ONE, 17(9), e0271011. Public Library of Science 10.1371/journal.pone.0271011

2021

Anghel, Nicoleta; Müller, Joachim; Serricchio, Mauro; Jelk, Jennifer; Bütikofer, Peter; Boubaker, Ghalia; Imhof, Dennis; Ramseier, Jessica; Desiatkina, Oksana; Paunescu, Emilia; Braga, Sophie Marie-Pierre; Heller, Manfred; Furrer, Julien; Hemphill, Andrew (2021). Cellular and Molecular Targets of Nucleotide-Tagged Trithiolato-Bridged Arene Ruthenium Complexes in the Protozoan Parasites Toxoplasma gondii and Trypanosoma brucei. International journal of molecular sciences, 22(19) Molecular Diversity Preservation International MDPI 10.3390/ijms221910787

Müller, Joachim; Heller, Manfred; Uldry, Anne-Christine; Braga, Sophie; Müller, Norbert (2021). Nitroreductase Activites in Giardia lamblia: ORF 17150 Encodes a Quinone Reductase with Nitroreductase Activity. Pathogens, 10(2), p. 129. MDPI AG 10.3390/pathogens10020129

Van Voorhis, Wesley C; Hulverson, Matthew A; Choi, Ryan; Huang, Wenlin; Arnold, Samuel L M; Schaefer, Deborah A; Betzer, Dana P; Vidadala, Rama S R; Lee, Sangun; Whitman, Grant R; Barrett, Lynn K; Maly, Dustin J; Riggs, Michael W; Fan, Erkang; Kennedy, Thomas J; Tzipori, Saul; Doggett, J Stone; Winzer, Pablo; Anghel, Nicoleta; Imhof, Dennis; ... (2021). One health therapeutics: Target-Based drug development for cryptosporidiosis and other apicomplexa diseases. Veterinary parasitology, 289, p. 109336. Elsevier 10.1016/j.vetpar.2020.109336

2020

Anghel, Nicoleta; Winzer, Pablo A.; Imhof, Dennis; Müller, Joachim; Langa, Javier; Rieder, Jessica; Barrett, Lynn K.; Vidadala, Rama Subba Rao; Huang, Wenlin; Choi, Ryan; Hulverson, Mathew A.; Whitman, Grant R.; Arnold, Samuel L.; Van Voorhis, Wesley C.; Ojo, Kayode K.; Maly, Dustin J.; Fan, Erkang; Hemphill, Andrew (2020). Comparative assessment of the effects of bumped kinase inhibitorson early zebrafish embryo development and pregnancy in mice. International journal of antimicrobial agents, 56(3), p. 106099. Elsevier 10.1016/j.ijantimicag.2020.106099

Müller, Joachim; Braga, Sophie; Uldry, Anne-Christine; Heller, Manfred; Müller, Norbert (2020). Comparative proteomics of three Giardia lamblia strains: investigation of antigenic variation in the post-genomic era. Parasitology, 147(9), pp. 1008-1018. Cambridge University Press 10.1017/S0031182020000657

Winzer, Pablo; Müller, Joachim; Imhof, Dennis; Ritler, Dominic; Uldry, Anne-Christine; Braga-Lagache, Sophie; Heller, Manfred; Ojo, Kayode K; Van Voorhis, Wesley C; Ortega-Mora, Luis-Miguel; Hemphill, Andrew (2020). Neospora caninum: Differential Proteome of Multinucleated Complexes Induced by the Bumped Kinase Inhibitor BKI-1294. Microorganisms, 8(6) MDPI 10.3390/microorganisms8060801

Lin, Yan; Ong, Yih Ching; Keller, Sarah; Karges, Johannes; Bouchene, Rafika; Manoury, Eric; Blacque, Olivier; Müller, Joachim; Anghel, Nicoleta; Hemphill, Andrew; Häberli, Cécile; Taki, Aya C; Gasser, Robin B; Cariou, Kevin; Keiser, Jennifer; Gasser, Gilles (2020). Synthesis, characterization and antiparasitic activity of organometallic derivatives of the anthelmintic drug albendazole. Dalton transactions, 49(20), pp. 6616-6626. Royal Society of Chemistry 10.1039/d0dt01107j

Winzer, Pablo Arnold; Anghel, Nicoleta; Imhof, Dennis; Balmer, Vreni; Ortega-Mora, Luis-Miguel; Ojo, Kayode K; Van Voorhis, Wesley C; Müller, Joachim; Hemphill, Andrew (2020). Neospora caninum: Structure and Fate of Multinucleated Complexes Induced by the Bumped Kinase Inhibitor BKI-1294. Pathogens, 9(5) MDPI AG 10.3390/pathogens9050382

Müller, Joachim; Winzer, Pablo A.; Samby, Kirandeep; Hemphill, Andrew (2020). In Vitro Activities of MMV Malaria Box Compounds against the Apicomplexan Parasite Neospora caninum, the Causative Agent of Neosporosis in Animals. Molecules, 25(6) Molecular Diversity Preservation International MDPI 10.3390/molecules25061460

Müller, Joachim; Vermathen, Martina; Leitsch, David; Vermathen, Peter; Müller, Norbert (2020). Metabolomic Profiling of Wildtype and Transgenic Giardia lamblia Strains by 1H HR-MAS NMR Spectroscopy. Metabolites, 10(2) MDPI 10.3390/metabo10020053

Heller, Manfred; Braga, Sophie; Müller, Norbert; Müller, Joachim (2020). Transfection With Plasmid Causing Stable Expression of a Foreign Gene Affects General Proteome Pattern in Giardia lamblia Trophozoites. Frontiers in cellular and infection microbiology, 10 Frontiers 10.3389/fcimb.2020.602756

Winzer, Pablo; Imhof, Dennis; Anghel, Nicoleta; Ritler, Dominic; Müller, Joachim; Boubaker, Ghalia; Aguado-Martinez, Adriana; Ortega-Mora, Luis-Miguel; Ojo, Kayode K; VanVoorhis, Wesley C; Hemphill, Andrew (2020). The Impact of BKI-1294 Therapy in Mice Infected With the Apicomplexan Parasite Neospora caninum and Re-infected During Pregnancy. Frontiers in veterinary science, 7, p. 587570. Frontiers Media 10.3389/fvets.2020.587570

Eberhard, Naja; Balmer, Vreni; Müller, Joachim; Müller, Norbert; Winter, Rolf; Pou, Soviti; Nilsen, Aaron; Riscoe, Mike; Francisco, Samuel; Leitao, Alexandre; Doggett, J Stone; Hemphill, Andrew (2020). Activities of Endochin-Like Quinolones Against in vitro Cultured Besnoitia besnoiti Tachyzoites. Frontiers in veterinary science, 7, p. 96. Frontiers Media 10.3389/fvets.2020.00096

2019

Hemphill, Andrew; Müller, Norbert; Müller, Joachim (2019). Comparative Pathobiology of the Intestinal Protozoan Parasites Giardia lamblia, Entamoeba histolytica, and Cryptosporidium parvum. Pathogens, 8(3) MDPI AG 10.3390/pathogens8030116

Müller, Joachim; Braga, Sophie; Heller, Manfred; Müller, Norbert (2019). Resistance formation to nitro drugs in Giardia lamblia: No common markers identified by comparative proteomics. International journal for parasitology. Drugs and drug resistance, 9, pp. 112-119. Elsevier 10.1016/j.ijpddr.2019.03.002

Silva Pinto Basto, Afonso; Anghel, Nicoleta; Rubbiani, Riccardo; Müller, Joachim; Stibal, David; Giannini, Federico; Süss-Fink, Georg; Balmer, Vreni; Gasser, Gilles; Furrer, Julien; Hemphill, Andrew (2019). Targeting of the mitochondrion by dinuclear thiolato-bridged arene ruthenium complexes in cancer cells and in the apicomplexan parasite Neospora caninum. Metallomics, 11(2), pp. 462-474. Royal Society of Chemistry 10.1039/C8MT00307F

Sánchez-Sánchez, Roberto; Ferre, Ignacio; Regidor-Cerrillo, Javier; Gutiérrez-Expósito, Daniel; Ferrer, Luis Miguel; Arteche-Villasol, Noive; Moreno-Gonzalo, Javier; Müller, Joachim; Aguado Martinez, Adriana; Pérez, Valentín; Hemphill, Andrew; Ortega-Mora, Luis Miguel; Benavides, Julio (2019). Virulence in Mice of a Toxoplasma gondii Type II Isolate Does Not Correlate With the Outcome of Experimental Infection in Pregnant Sheep. Frontiers in cellular and infection microbiology, 8(436), p. 436. Frontiers 10.3389/fcimb.2018.00436

Müller, Joachim; Manser, Vera; Hemphill, Andrew (2019). In vitro treatment of Besnoitia besnoiti with the naphto-quinone buparvaquone results in marked inhibition of tachyzoite proliferation, mitochondrial alterations and rapid adaptation of tachyzoites to increased drug concentrations. Parasitology, 146(1), pp. 112-120. Cambridge University Press 10.1017/S0031182018000975

Ritler, Dominic; Rufener, Reto; Li, Jia V.; Kämpfer, Urs; Müller, Joachim; Bühr, Claudia; Schürch, Stefan; Lundström Stadelmann, Britta (2019). In vitro metabolomic footprint of the Echinococcus multilocularis metacestode. Scientific reports, 9(1), p. 19438. Springer Nature 10.1038/s41598-019-56073-y

Müller, Joachim; Müller, Norbert (2019). Nitroreductases of bacterial origin in Giardia lamblia : Potential role in detoxification of xenobiotics. MicrobiologyOpen, 8(10), pp. 1-9. Wiley 10.1002/mbo3.904

2018

Anghel, Nicoleta; Balmer, Vreni; Müller, Joachim; Winzer, Pablo Arnold; Aguado Martinez, Adriana; Roozbehani, Mona; Pou, Sovitj; Nilsen, Aaron; Riscoe, Michael; Doggett, J Stone; Hemphill, Andrew (2018). Endochin-Like Quinolones Exhibit Promising Efficacy Against Neospora Caninum in vitro and in Experimentally Infected Pregnant Mice. Frontiers in veterinary science, 5, p. 285. Frontiers Media 10.3389/fvets.2018.00285

Vermathen, Martina; Müller, Joachim; Furrer, Julien; Müller, Norbert; Vermathen, Peter (2018). 1H HR-MAS NMR spectroscopy to study the metabolome of the protozoan parasite Giardia lamblia. Talanta, 188, pp. 429-441. Elsevier 10.1016/j.talanta.2018.06.006

De Amorim Cardoso, Rita Isabel; Wang, Junhua; Müller, Joachim; Rupp, Sebastian Dominic Alexander; Leitão, Alexandre; Hemphill, Andrew (2018). Modulation of cis- and trans- Golgi and the Rab9A-GTPase during infection by Besnoitia besnoiti, Toxoplasma gondii and Neospora caninum. Experimental parasitology, 187, pp. 75-85. Elsevier 10.1016/j.exppara.2018.02.008

Rufener, Reto; Ritler, Dominic; Zielinski, Jana; Dick, Luca; da Silva, Emerson Teixeira; da Silva Araujo, Adriele; Joekel, Deborah Elisabeth; Czock, David; Göpfert, Christine; Moraes, Adriana Marques; de Souza, Marcus Vinicius Nora; Müller, Joachim; Mevissen, Meike; Hemphill, Andrew; Lundström-Stadelmann, Britta (2018). Activity of mefloquine and mefloquine derivatives against Echinococcus multilocularis. International journal for parasitology. Drugs and drug resistance, 8(2), pp. 331-340. Elsevier 10.1016/j.ijpddr.2018.06.004

Müller, Joachim; Hemphill, Andrew; Müller, Norbert (2018). Physiological aspects of nitro drug resistance in Giardia lamblia. International journal for parasitology. Drugs and drug resistance, 8(2), pp. 271-277. Elsevier 10.1016/j.ijpddr.2018.04.008

2017

Harmse, Rozanne; Wong, Ho Ning; Smit, Frans J; Müller, Joachim; Hemphill, Andrew; N'Da, David D; Haynes, Richard K (2017). Activities of 11-Azaartemisinin and N-Sulfonyl Derivatives against Neospora caninum and Comparative Cytotoxicities. ChemMedChem, 12(24), pp. 2094-2098. Wiley-VCH 10.1002/cmdc.201700600

Hulverson, Matthew A; Choi, Ryan; Arnold, Samuel L M; Schaefer, Deborah A; Hemphill, Andrew; McCloskey, Molly C; Betzer, Dana P; Müller, Joachim; Vidadala, Rama S R; Whitman, Grant R; Rivas, Kasey L; Barrett, Lynn K; Hackman, Robert C; Love, Melissa S; McNamara, Case W; Shaughnessy, Thomas K; Kondratiuk, Alison; Kurnick, Matthew; Banfor, Patricia N; Lynch, James J; ... (2017). Advances in bumped kinase inhibitors for human and animal therapy for cryptosporidiosis. International journal for parasitology, 47(12), pp. 753-763. Elsevier 10.1016/j.ijpara.2017.08.006

Müller, Joachim; Aguado Martinez, Adriana; Laleu, Benoît; Balmer, Vreni; Ritler, Dominic; Hemphill, Andrew (2017). In vitro screening of the open source Pathogen Box identifies novel compounds with profound activities against Neospora caninum. International journal for parasitology, 47(12), pp. 801-809. Elsevier 10.1016/j.ijpara.2017.06.002

Müller, Joachim; Aguado Martinez, Adriana; Ortega-Mora, Luis-Miguel; Moreno-Gonzalo, Javier; Ferre, Ignacio; Hulverson, Matthew A; Choi, Ryan; McCloskey, Molly C; Barrett, Lynn K; Maly, Dustin J; Ojo, Kayode K; Van Voorhis, Wes; Hemphill, Andrew (2017). Development of a murine vertical transmission model for Toxoplasma gondii oocyst infection and studies on the efficacy of bumped kinase inhibitor (BKI)-1294 and the naphthoquinone buparvaquone against congenital toxoplasmosis. Journal of antimicrobial chemotherapy, 72(8), pp. 2334-2341. Oxford University Press 10.1093/jac/dkx134

Silva Pinto Basto, Afonso; Müller, Joachim; Rubbiani, Riccardo; Stibal, David; Giannini, Federico; Süss-Fink, Georg; Balmer, Vreni; Hemphill, Andrew; Gasser, Gilles; Furrer, Julien (2017). Characterization of the Activities of Dinuclear Thiolato-Bridged Arene Ruthenium Complexes against Toxoplasma gondii. Antimicrobial agents and chemotherapy, 61(9), e01031-17. American Society for Microbiology 10.1128/AAC.01031-17

Müller, Joachim; Aguado Martinez, Adriana; Balmer, Vreni; Maly, Dustin J; Fan, Erkang; Ortega-Mora, Luis-Miguel; Ojo, Kayode K; Van Voorhis, Wesley C; Hemphill, Andrew (2017). Two novel calcium-dependent kinase 1-inhibitors interfere with vertical transmission in mice infected with Neospora caninum tachyzoites. Antimicrobial agents and chemotherapy, 61(4) American Society for Microbiology 10.1128/AAC.02324-16

Serra, Fabienne Heirangi; Müller, Joachim; Gray, John; Lüthi, Ramona; Dudas, Sandor; Czub, Stefanie; Seuberlich, Torsten (2017). PrP-C1 fragment in cattle brains reveals features of the transmissible spongiform encephalopathy associated PrP(sc). Brain research, 1659, pp. 19-28. Elsevier 10.1016/j.brainres.2017.01.015

2016

Leitsch, David; Müller, Joachim; Müller, Norbert (2016). Evaluation of Giardia lamblia thioredoxin reductase as drug activating enzyme and as drug target. International journal for parasitology. Drugs and drug resistance, 6(3), pp. 148-153. Elsevier 10.1016/j.ijpddr.2016.07.003

Müller, Joachim; Hemphill, Andrew (2016). Drug target identification in protozoan parasites. Expert opinion on drug discovery, 11(8), pp. 815-824. Taylor & Francis 10.1080/17460441.2016.1195945

Van Voorhis, Wesley C; Adams, John H; Adelfio, Roberto; Ahyong, Vida; Akabas, Myles H; Alano, Pietro; Alday, Aintzane; Alemán Resto, Yesmalie; Alsibaee, Aishah; Alzualde, Ainhoa; Andrews, Katherine T; Avery, Simon V; Avery, Vicky M; Ayong, Lawrence; Baker, Mark; Baker, Stephen; Ben Mamoun, Choukri; Bhatia, Sangeeta; Bickle, Quentin; Bounaadja, Lotfi; ... (2016). Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. PLoS pathogens, 12(7), e1005763. Public Library of Science 10.1371/journal.ppat.1005763

Hostettler, Isabel; Müller, Joachim; Hemphill, Andrew (2016). In Vitro Screening of the Open-Source Medicines for Malaria Venture Malaria Box Reveals Novel Compounds with Profound Activities against Theileria annulata Schizonts. Antimicrobial agents and chemotherapy, 60(6), pp. 3301-3308. American Society for Microbiology 10.1128/AAC.02801-15

Aguado Martinez, Adriana; Silva Pinto Basto, Afonso; Müller, Joachim; Balmer, Vreni; Manser, Vera; Leitão, Alexandre; Hemphill, Andrew (2016). N-terminal fusion of a toll-like receptor 2-ligand to a Neospora caninum chimeric antigen efficiently modifies the properties of the specific immune response. Parasitology, 143(5), pp. 606-616. Cambridge University Press 10.1017/S0031182016000056

Hemphill, Andrew; Aguado Martinez, Adriana; Müller, Joachim (2016). Approaches for the vaccination and treatment of Neospora caninum infections in mice and ruminant models. Parasitology, 143(3), pp. 245-259. Cambridge University Press 10.1017/S0031182015001596

Müller, Joachim; Aguado Martinez, Adriana; Manser, Vera; Wong, Ho Ning; Haynes, Richard K; Hemphill, Andrew (2016). Repurposing of antiparasitic drugs: the hydroxy-naphthoquinone buparvaquone inhibits vertical transmission in the pregnant neosporosis mouse model. Veterinary research, 47, p. 32. BioMed Central 10.1186/s13567-016-0317-1

Müller, Norbert; Müller, Joachim (2016). Giardia. In: Walochnik, Julia; Duchêne, Michael (eds.) Molecular Parasitology (pp. 93-114). Wien: Springer Verlag 10.1007/978-3-7091-1416-2_4

2015

Küster, Tatiana; Lundström-Stadelmann, Britta; Rufener, Reto; Risch, Corina; Müller, Joachim; Hemphill, Andrew (2015). Oral treatments of Echinococcus multilocularis-infected mice with the antimalarial drug mefloquine that potentially interacts with parasite ferritin and cystatin. International journal of antimicrobial agents, 46(5), pp. 546-551. Elsevier 10.1016/j.ijantimicag.2015.07.016

Winzer, Pablo Arnold; Müller, Joachim; Aguado Martinez, Adriana; Rahman, Mahbubur; Balmer, Vreni; Manser, Vera; Ortega-Mora, Luis Miguel; Ojo, Kayode K; Fan, Erkang; Maly, Dustin J; Van Voorhis, Wesley C; Hemphill, Andrew (2015). In Vitro and In Vivo Effects of the Bumped Kinase Inhibitor 1294 in the Related Cyst-Forming Apicomplexans Toxoplasma gondii and Neospora caninum. Antimicrobial agents and chemotherapy, 59(10), pp. 6361-6374. American Society for Microbiology 10.1128/AAC.01236-15

Müller, Joachim; Rout, Samuel; Leitsch, David; Vaithilingam, Jathana; Hehl, Adrian; Müller, Norbert (2015). Comparative characterisation of two nitroreductases from Giardia lamblia as potential activators of nitro compounds. International journal for parasitology. Drugs and drug resistance, 5(2), pp. 37-43. Elsevier 10.1016/j.ijpddr.2015.03.001

Arranz Solis, David; Aguado Martinez, Adriana; Müller, Joachim; Regidor-Cerrillo, Javier; Ortega-Mora, Luis Miguel; Hemphill, Andrew (2015). Dose-dependent effects of experimental infection with the virulent Neospora caninum Nc-Spain7 isolate in a pregnant mouse model. Veterinary parasitology, 211(3-4), pp. 133-140. Elsevier 10.1016/j.vetpar.2015.05.021

Müller, Joachim; Balmer, Vreni; Winzer, Pablo Arnold; Rahman, Mahbubur; Manser, Vera; Haynes, Richard K; Hemphill, Andrew (2015). In vitro effects of new artemisinin derivatives in Neospora caninum-infected human fibroblasts. International journal of antimicrobial agents, 46(1), pp. 88-93. Elsevier 10.1016/j.ijantimicag.2015.02.020

Müller, Joachim; Aguado Martinez, Adriana; Manser, Vera; Balmer, Vreni; Winzer, Pablo Arnold; Ritler, Dominic; Hostettler, Isabel; Arranz Solis, David; Ortega-Mora, Luis; Hemphill, Andrew (2015). Buparvaquone is active against Neospora caninum in vitro and in experimentally infected mice. International journal for parasitology. Drugs and drug resistance, 5(1), pp. 16-25. Elsevier 10.1016/j.ijpddr.2015.02.001

2014

Hostettler, Isabel; Müller, Joachim; Stephens, Chad E; Haynes, Richard; Hemphill, Andrew (2014). A quantitative reverse-transcriptase PCR assay for the assessment of drug activities against intracellular Theileria annulata schizonts. International journal for parasitology. Drugs and drug resistance, 4(3), pp. 201-209. Elsevier 10.1016/j.ijpddr.2014.09.003

Lundström-Stadelmann, Britta; Aeschbacher, Denise; Huber, Cristina; Spiliotis, Markus; Müller, Joachim; Hemphill, Andrew (2014). Profound activity of the anti-cancer drug bortezomib against Echinococcus multilocularis metacestodes identifies the proteasome as a novel drug target for cestodes. PLoS neglected tropical diseases, 8(12), e3352. Public Library of Science 10.1371/journal.pntd.0003352

Hemphill, Andrew; Lundström-Stadelmann, Britta; Rufener, Reto; Spiliotis, Markus; Boubaker, Ghalia; Müller, Joachim; Müller, Norbert; Gorgas, Daniela; Gottstein, Bruno (2014). Treatment of echinococcosis: albendazole and mebendazole - what else? Parasite, 21, p. 70. Princeps Editions 10.1051/parasite/2014073

Müller, Joachim; Vaithilingam, Jathana; Rosner, Judah Lee; Müller, Norbert (2014). Escherichia coli are susceptible to thiazolides if the tolc efflux system is inhibited. Journal of Developing Drugs, 3(2), p. 1000124. OMICS Group 10.4172/2329-6631.1000124

Ojo, Kayode K; Reid, Molly C; Kallur Siddaramaiah, Latha; Müller, Joachim; Winzer, Pablo Arnold; Zhang, Zhongsheng; Keyloun, Katelyn R; Vidadala, Rama Subba Rao; Merritt, Ethan A; Hol, Wim G J; Maly, Dustin J; Fan, Erkang; Van Voorhis, Wesley C; Hemphill, Andrew (2014). Neospora caninum calcium-dependent protein kinase 1 is an effective drug target for neosporosis therapy. PLoS ONE, 9(3), e92929. Public Library of Science 10.1371/journal.pone.0092929

2013

Hemphill, Andrew; Debache, Karim; Monney, Thierry; Schorer, Michelle; Gouinaud, Christophe; Alaeddine, Ferial; Müller, Norbert; Müller, Joachim (2013). Proteins mediating the Neospora caninum-host cell interaction as targets for vaccination. Frontiers in Bioscience (Elite Edition), 5(1), pp. 23-36. Frontiers in Bioscience

Müller, Joachim; Schildknecht, Patricia; Müller, Norbert (2013). Metabolism of nitro drugs metronidazole and nitazoxanide in Giardia lamblia: characterization of a novel nitroreductase (GlNR2). Journal of antimicrobial chemotherapy, 68(8), pp. 1781-1789. Oxford University Press 10.1093/jac/dkt106

Hemphill, Andrew; Müller, Norbert; Müller, Joachim (2013). Thiazolides, a Novel Class of Anti-Infective Drugs, Effective Against Viruses, Bacteria, Intracellular and Extracellular Protozoan Parasites and Proliferating Mammalian Cells. Anti-infective agents in medicinal chemistry, 11(1), pp. 22-30. Bentham Science 10.2174/22113626130103

2012

Sidler, D; Brockmann, A; Mueller, J; Nachbur, U; Corazza, N; Renzulli, P; Hemphill, A; Brunner, T (2012). Thiazolide-induced apoptosis in colorectal cancer cells is mediated via the Jun kinase-Bim axis and reveals glutathione-S-transferase P1 as Achilles' heel. Oncogene, 31(37), pp. 4095-106. Basingstoke, UK: Nature Publishing Group 10.1038/onc.2011.575

Reinmann, Karin; Müller, Norbert; Kuhnert, Peter; Campero, Carlos M.; Leitsch, David; Hess, M; Henning, K; Fort, M; Müller, Joachim; Gottstein, Bruno; Frey, Caroline (2012). Tritrichomonas foetus isolates from cats and cattle show minor genetic differences in unrelated loci ITS-2 and EF-1alpha. Veterinary parasitology, 185(2-4), pp. 138-44. Amsterdam: Elsevier 10.1016/j.vetpar.2011.09.032

Manneck, Theresia; Keiser, Jennifer; Müller, Joachim (2012). Mefloquine interferes with glycolysis in schistosomula of Schistosoma mansoni via inhibition of enolase. Parasitology, 139(4), pp. 497-505. Cambridge University Press 10.1017/S0031182011002204

2011

Mejri, N.; Muller, J.; Gottstein, B. (2011). Intraperitoneal murine Echinococcus multilocularis infection induces differentiation of TGF-beta-expressing DCs that remain immature. Parasite immunology, 33(9), pp. 471-82. Oxford: Blackwell Scientific Publications 10.1111/j.1365-3024.2011.01303.x

Müller, J.; Müller, N.; Hemphill, A. (2011). Drugs and drug targets in Neospora caninum and related apicomplexans. In: Becker, Katja (ed.) Apicomplexan Parasites. Drug discovery in Infectious Diseases: Vol. 2 (pp. 359-371). Chichester: John Wiley & Sons

Müller, J.; Hemphill, A.; Müller, N. (2011). Treatment of giardiasis and drug resistance. In: Lujan, Hugo D.; Svärd, Staffan (eds.) Giardia - a model organism. Heidelberg: Springer Verlag

Muller, J.; Hemphill, A. (2011). Drug target identification in intracellular and extracellular protozoan parasites. Current topics in medicinal chemistry, 11(16), pp. 2029-38. Hilversum: Bentham Science Publishers 10.2174/156802611796575876

Nillius, Dorothea; Müller, Joachim; Müller, Norbert (2011). Nitroreductase (GlNR1) increases susceptibility of Giardia lamblia and Escherichia coli to nitro drugs. Journal of antimicrobial chemotherapy, 66(5), pp. 1029-35. Oxford: Oxford University Press 10.1093/jac/dkr029

2010

Gottstein, Bruno; Wittwer, Matthias; Schild, Marc; Merli, Michael; Leib, Stephen L.; Müller, Norbert; Müller, Joachim; Jaggi, Rolf (2010). Hepatic gene expression profile in mice perorally infected with Echinococcus multilocularis eggs. PLoS ONE, 5(4), e9779. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0009779

Hemphill, A.; Stadelmann, B.; Scholl, S.; Muller, J.; Spiliotis, M.; Muller, N.; Gottstein, B.; Siles-Lucas, M. (2010). Echinococcus metacestodes as laboratory models for the screening of drugs against cestodes and trematodes. Parasitology, 137(3), pp. 569-87. London: Cambridge University Press 10.1017/S003118200999117X

Lundström-Stadelmann, Britta; Scholl, Sabrina; Muller, J.; Hemphill, A. (2010). Application of an in vitro drug screening assay based on the release of phosphoglucose isomerase to determine the structure-activity relationship of thiazolides against Echinococcus multilocularis metacestodes. Journal of antimicrobial chemotherapy, 65(3), pp. 512-9. Oxford: Oxford University Press 10.1093/jac/dkp490

Stadelmann, B.; Spiliotis, M.; Muller, J.; Scholl, S.; Muller, N.; Gottstein, B.; Hemphill, A. (2010). Echinococcus multilocularis phosphoglucose isomerase (EmPGI): a glycolytic enzyme involved in metacestode growth and parasite-host cell interactions. International journal for parasitology, 40(13), pp. 1563-74. Kidlington, UK: Elsevier 10.1016/j.ijpara.2010.05.009

2009

Debache, Karim; Alaeddine, Ferial; Guionaud, Christophe; Monney, Thierry; Müller, Joachim; Strohbusch, Maria; Leib, Stephen L.; Grandgirard, Denis; Hemphill, Andrew (2009). Vaccination with recombinant NcROP2 combined with recombinant NcMIC1 and NcMIC3 reduces cerebral infection and vertical transmission in mice experimentally infected with Neospora caninum tachyzoites. International journal for parasitology, 39(12), pp. 1373-1384. Kidlington, UK: Elsevier 10.1016/j.ijpara.2009.04.006

Schmuckli-Maurer, Jacqueline; Casanova, Carlo; Schmied, Stéfanie; Affentranger, Sarah; Parvanova, Iana; Kang'a, Simon; Nene, Vishvanath; Katzer, Frank; McKeever, Declan; Müller, Joachim; Bishop, Richard; Pain, Arnab; Dobbelaere, Dirk; Rodrigues, Mauricio Martins (2009). Expression Analysis of the Theileria parva Subtelomere-Encoded Variable Secreted Protein Gene Family. PLoS ONE, 4(3), e4839. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0004839

Hemphill, A.; Muller, J. (2009). Alveolar and cystic echinococcosis: towards novel chemotherapeutical treatment options. Journal of helminthology, 83(2), pp. 99-111. Cambridge: Cambridge University Press 10.1017/S0022149X0928936X

Muller, J.; Limban, C.; Stadelmann, B.; Missir, A.V.; Chirita, I.C.; Chifiriuc, M.C.; Nitulescu, G.M.; Hemphill, A. (2009). Thioureides of 2-(phenoxymethyl)benzoic acid 4-R substituted: a novel class of anti-parasitic compounds. Parasitology international, 58(2), pp. 128-35. Amsterdam: Elsevier 10.1016/j.parint.2008.12.003

Müller, Joachim; Nillius, Dorothea; Hehl, A.; Hemphill, Andrew; Müller, Norbert (2009). Stable expression of Escherichia coli beta-glucuronidase A (GusA) in Giardia lamblia: application to high-throughput drug susceptibility testing. Journal of antimicrobial chemotherapy, 64(6), pp. 1187-1191. Oxford: Oxford University Press 10.1093/jac/dkp363

2008

Müller, Joachim; Naguleswaran, Arunasalam; Müller, Norbert; Hemphill, Andrew (2008). Neospora caninum: functional inhibition of protein disulfide isomerase by the broad-spectrum anti-parasitic drug nitazoxanide and other thiazolides. Experimental parasitology, 118(1), pp. 80-8. Amsterdam: Elsevier 10.1016/j.exppara.2007.06.008

Müller, Joachim; Ley, Serej; Felger, Ingrid; Hemphill, Andrew; Müller, Norbert (2008). Identification of differentially expressed genes in a Giardia lamblia WB C6 clone resistant to nitazoxanide and metronidazole. Journal of antimicrobial chemotherapy, 62(1), pp. 72-82. Oxford University Press 10.1093/jac/dkn142

2007

Sterk, Maaike; Müller, Joachim; Hemphill, Andrew; Müller, Norbert (2007). Characterization of a Giardia lamblia WB C6 clone resistant to the isoflavone formononetin. Microbiology, 153(Pt 12), pp. 4150-8. Reading, UK: Society for General Microbiology 10.1099/mic.0.2007/010041-0

Hemphill, Andrew; Spicher, Martin; Lundström-Stadelmann, Britta; Müller, Joachim; Naguleswaran, Arunasalam; Gottstein, Bruno; Walker, M (2007). Innovative chemotherapeutical treatment options for alveolar and cystic echinococcosis. Parasitology, 134(Pt 12), pp. 1657-70. London: Cambridge University Press 10.1017/S0031182007003198

Müller, Joachim; Sterk, Maaike; Hemphill, Andrew; Müller, Norbert (2007). Characterization of Giardia lamblia WB C6 clones resistant to nitazoxanide and to metronidazole. Journal of antimicrobial chemotherapy, 60(2), pp. 280-7. Oxford: Oxford University Press 10.1093/jac/dkm205

Esposito, Marco; Moores, Shelley; Naguleswaran, Arunasalam; Müller, Joachim; Hemphill, Andrew (2007). Induction of tachyzoite egress from cells infected with the protozoan Neospora caninum by nitro- and bromo-thiazolides, a class of broad-spectrum anti-parasitic drugs. International journal for parasitology, 37(10), pp. 1143-52. Kidlington, UK: Elsevier 10.1016/j.ijpara.2007.03.007

Müller, Joachim; Wastling, Jonathan; Sanderson, Sanya; Müller, Norbert; Hemphill, Andrew (2007). A novel Giardia lamblia nitroreductase, GlNR1, interacts with nitazoxanide and other thiazolides. Antimicrobial agents and chemotherapy, 51(6), pp. 1979-86. Washington, D.C.: American Society for Microbiology 10.1128/AAC.01548-06

Srinivasan, Sangeetha; Mueller, Joachim; Suana, Angela; Hemphill, Andrew (2007). Vaccination with microneme protein NcMIC4 increases mortality in mice inoculated with Neospora caninum. Journal of parasitology, 93(5), pp. 1046-55. Lawrence, Kans.: American Society of Parasitologists 10.1645/GE-1181R1.1

Hemphill, A; Müller, N; Müller, J (2007). Structure-funktion relationship of thiazolides, a novel class of antiparasitic drugs, investigated in intracellular protozoan parasites and larvalstage cestodes. Anti-infective agents in medicinal chemistry(6), pp. 273-282. Sharjah: Bentham Science

2006

Müller, Joachim; Rühle, Géraldine; Müller, Norbert; Rossignol, Jean-François; Hemphill, Andrew (2006). In vitro effects of thiazolides on Giardia lamblia WB clone C6 cultured axenically and in coculture with Caco2 cells. Antimicrobial agents and chemotherapy, 50(1), pp. 162-70. Washington, D.C.: American Society for Microbiology 10.1128/AAC.50.1.162-170.2006

Hemphill, Andrew; Mueller, Joachim; Esposito, Marco (2006). Nitazoxanide, a broad-spectrum thiazolide anti-infective agent for the treatment of gastrointestinal infections. Expert opinion on pharmacotherapy, 7(7), pp. 953-64. London: Informa Healthcare 10.1517/14656566.7.7.953

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