Congenital hypothyroidism in a kitten resulting in decreased IGF-I concentration and abnormal liver function tests

Quante, S.; Fracassi, F.; Gorgas, D.; Kircher, P.R.; Boretti, F.S.; Ohlerth, S.; Reusch, C.E. (2010). Congenital hypothyroidism in a kitten resulting in decreased IGF-I concentration and abnormal liver function tests. Journal of feline medicine and surgery, 12(6), pp. 487-90. London: Sage 10.1016/j.jfms.2010.01.013

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A 7-month-old male kitten was presented with chronic constipation and retarded growth. Clinical examination revealed disproportional dwarfism with mild skeletal abnormalities and a palpable thyroid gland. The presumptive diagnosis of congenital hypothyroidism was confirmed by low serum total thyroxine (tT(4)) concentration prior to and after the administration of thyroid stimulation hormone (TSH), increased endogenous TSH concentration and abnormal thyroid scintigraphic scan. The kitten had abnormal liver function tests and decreased insulin-like growth factor 1 (IGF-1) concentration, both of which returned to normal in correspondence with an improvement of the clinical signs after 6 weeks of thyroxine therapy. Congenital hypothyroidism is a rare disease that may present with considerable variation in clinical manifestation. In cases in which clinical signs are ambiguous, disorders such as portosystemic shunt and hyposomatotropism have to be taken into account as differential diagnosis. As hypothyroidism may be associated with abnormal liver function tests and low IGF-1 concentrations, test results have to be interpreted carefully.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Clinical Radiology
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV)

UniBE Contributor:

Schweizer, Daniela Esther; Kircher, Patrick Robert and Ohlerth, Stefanie

Subjects:

500 Science > 590 Animals (Zoology)
600 Technology > 610 Medicine & health

ISSN:

1098-612X

Publisher:

Sage

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:36

Last Modified:

01 Nov 2017 12:45

Publisher DOI:

10.1016/j.jfms.2010.01.013

PubMed ID:

20223692

Web of Science ID:

000279090600011

BORIS DOI:

10.7892/boris.14363

URI:

https://boris.unibe.ch/id/eprint/14363 (FactScience: 221318)

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