Genetic Variants Affecting Skeletal Morphology in Domestic Dogs.

Bannasch, Danika L.; Baes, Christine F.; Leeb, Tosso (2020). Genetic Variants Affecting Skeletal Morphology in Domestic Dogs. Trends in genetics, 36(8), pp. 598-609. Elsevier 10.1016/j.tig.2020.05.005

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Purebred dog breeds provide a powerful resource for the discovery of genetic variants affecting skeletal morphology. Domesticated and subsequently purebred dogs have undergone strong artificial selection for a broad range of skeletal variation, which include both the size and shapes of their bones. While the phenotypic variation between breeds is high, within-breed morphological variation is typically low. Approaches for defining genetic variants associated with canine morphology include quantitative within-breed analyses, as well as across-breed analyses, using breed standards as proxies for individual measurements. The ability to identify variants across the genomes of individual dogs can now be paired with precise measures of morphological variation to define the genetic interactions and the phenotypic effect of variants on skeletal morphology.

Item Type:

Journal Article (Review Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Institute of Genetics
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)

UniBE Contributor:

Baes, Christine Francoise and Leeb, Tosso

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 590 Animals (Zoology)
600 Technology > 610 Medicine & health

ISSN:

0168-9525

Publisher:

Elsevier

Language:

English

Submitter:

Tosso Leeb

Date Deposited:

09 Jun 2020 08:49

Last Modified:

16 Jul 2020 01:32

Publisher DOI:

10.1016/j.tig.2020.05.005

PubMed ID:

32487495

Uncontrolled Keywords:

Canis lupus familiaris bone breed genomic height inherited morphology

BORIS DOI:

10.7892/boris.144465

URI:

https://boris.unibe.ch/id/eprint/144465

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