Hypertonic saline for fluid resuscitation in ICU patients post-cardiac surgery (HERACLES): a double-blind randomized controlled clinical trial.

Pfortmüller, Carmen A.; Kindler, Manuel; Schenk, Noelle; Messmer, Anna S.; Hess, Benjamin; Jakob, Laura; Wenger, Stefanie; Waskowski, Jan; Zuercher, Patrick; Stoehr, Frederik; Jakob, Stephan M.; Englberger, Lars; Schefold, Joerg C. (2020). Hypertonic saline for fluid resuscitation in ICU patients post-cardiac surgery (HERACLES): a double-blind randomized controlled clinical trial. Intensive care medicine, 46(9), pp. 1683-1695. Springer-Verlag 10.1007/s00134-020-06132-0

[img] Text
2020 - Pfortmüller - Intensive Care Medicine - PMID 32519005.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (1MB) | Request a copy

PURPOSE

Recent evidence questions a liberal approach to fluid resuscitation in intensive care unit (ICU) patients. Here, we assess whether use of hypertonic saline applied as single infusion at ICU admission after cardiac surgery can reduce cumulative perioperative fluid volume.

METHODS

Prospective randomized double-blind single-center clinical trial investigates effects of a single infusion of hypertonic saline (HS) versus normal saline (comparator). Primary endpoint was the cumulative amount of fluid administered in patients in the hypertonic saline versus the 0.9% saline groups (during ICU stay). Upon ICU admission, patients received a single infusion of 5 ml/kg body weight of 7.3% NaCl (or 0.9% NaCl) over 60 min. Patients undergoing cardiac surgery for elective valvular and/or coronary heart disease were included. Patients with advanced organ dysfunction, infection, and/or patients on chronic steroid medication were excluded.

RESULTS

A total of 101 patients were randomized to receive the study intervention (HS n = 53, NS n = 48). Cumulative fluid intake on the ICU (primary endpoint) did not differ between the HS and the NS groups [median 3193 ml (IQR 2052-4333 ml) vs. 3345 ml (IQR 2332-5043 ml)]. Postoperative urinary output until ICU discharge was increased in HS-treated patients [median 2250 ml (IQR 1640-2690 ml) vs. 1545 ml (IQR 1087-1976 ml)], and ICU fluid balance was lower in the HS group when compared to the NS group [296 ml (IQR - 441 to 1412 ml) vs. 1137 ml (IQR 322-2660 ml)].

CONCLUSION

In a monocentric prospective double-blind randomized clinical trial, we observed that hypertonic saline did not reduce the total fluid volume administered on the ICU in critically ill cardiac surgery patients. Hypertonic saline infusion was associated with timely increase in urinary output. Variations in electrolyte and acid-base homeostasis were transient, but substantial in all patients.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiovascular Surgery
04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic of Intensive Care

UniBE Contributor:

Pfortmüller, Carmen; Kindler, Manuel; Messmer, Anna Sarah; Hess, Benjamin; Jakob, Laura Valeria; Wenger, Stefanie; Waskowski, Jan; Zürcher, Patrick; Stöhr, Frederik; Jakob, Stephan; Englberger, Lars and Schefold, Jörg Christian

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0342-4642

Publisher:

Springer-Verlag

Language:

English

Submitter:

Jsabelle Arni

Date Deposited:

26 Jun 2020 17:41

Last Modified:

06 Sep 2020 01:32

Publisher DOI:

10.1007/s00134-020-06132-0

PubMed ID:

32519005

Uncontrolled Keywords:

Cardiac surgical procedures Critical illness Crystalloid solutions Fluid overload Fluid therapy Hemodynamics Hypertonic saline Perioperative period

BORIS DOI:

10.7892/boris.144666

URI:

https://boris.unibe.ch/id/eprint/144666

Actions (login required)

Edit item Edit item
Provide Feedback