Inflammatory myofibroblastic tumor of the liver: A case report and review of literature.

Filips, Alexandra; Maurer, Martin H.; Montani, Matteo; Beldi, Guido; Lachenmayer, Anja (2020). Inflammatory myofibroblastic tumor of the liver: A case report and review of literature. World journal of hepatology, 12(4), pp. 170-183. Baishideng Publishing Group Inc 10.4254/wjh.v12.i4.170

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BACKGROUND Inflammatory myofibroblastic tumors of the liver (IMTL) are extremely rare neoplasms and very little is known about their clinical presentation, pathogenesis, and biological behavior. Due to their absolute rarity, it is almost impossible to obtain a definite diagnosis without histological examination. Because of their intermediate biological behavior with the risk for local recurrence and metastases, surgical resection is recommend whenever IMTL is suspect. CASE SUMMARY We herein present a case of an otherwise healthy 32-year-old woman who presented with intermittent fever, unclear anemia, malaise and right flank pain 4 mo postpartum. The liver mass in segment IVa/b was highly FDG avid in the positron emission tomography-computed tomography. Hepatic resection was performed achieving a negative resection margin and an immediate resolution of all clinical symptoms. Histological analysis diagnosed the rare finding of an inflammatory myofibroblastic tumor of the liver and revealed cytoplasmic anaplastic lymphoma kinase expression by immunohistochemistry. Twelve months follow-up magnetic resonance imaging showed no recurrence and no metastases in the fully recovered patient. CONCLUSION IMTLs are extremely rare and difficult to diagnose. Due to their intermediate biological behavior, surgical resection should be perform whenever feasible and patients should be followed-up in order to detect recurrence and metastasis as early as possible.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery
04 Faculty of Medicine > Service Sector > Institute of Pathology
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine

UniBE Contributor:

Filips, Alexandra; Maurer, Martin; Montani, Matteo; Beldi, Guido and Lachenmayer, Anja

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1948-5182

Publisher:

Baishideng Publishing Group Inc

Language:

English

Submitter:

Maria de Fatima Henriques Bernardo

Date Deposited:

21 Jul 2020 11:06

Last Modified:

25 Jul 2020 23:07

Publisher DOI:

10.4254/wjh.v12.i4.170

PubMed ID:

32685109

Uncontrolled Keywords:

Anaplastic lymphoma kinase-expression Case report Hepatic Inflammatory Inflammatory myofibroblastic tumor Review

BORIS DOI:

10.7892/boris.145282

URI:

https://boris.unibe.ch/id/eprint/145282

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