Sleep-learning Impairs Subsequent Wake-learning

Ruch, Simon; Züst, Marc Alain; Henke, Katharina (2020). Sleep-learning Impairs Subsequent Wake-learning (bioRxiv). Cold Spring Harbor Laboratory 10.1101/2020.07.16.206482

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Humans can unconsciously acquire new information during deep sleep. Although sleep-played information can guide behavior during subsequent wakefulness, sleep-formed memories cannot be remembered consciously after awakening. We explored whether sleep-learning might expedite conscious learning during subsequent wakefulness by providing a first bout of carving a new memory trace, which ensuing wake-learning can build on. We analyzed previously unreported data acquired in a recent study on vocabulary learning during slow-wave sleep (Züst et al., 2019, Curr Biol). Sleep-played vocabulary was successfully retrieved in an implicit memory test administered following awakening. However, sleep-learning diminished instead of increased wake relearning of the same vocabulary. We speculate that vocabulary learning during sleep may have interfered with the synaptic down-scaling of hippocampal and neocortical language-related neurons, which were then too saturated for further potentiation required for the wake-relearning of the same vocabulary.

Item Type:	Working Paper
Division/Institute:	07 Faculty of Human Sciences > Institute of Psychology > Weitere Forschungsgruppen 07 Faculty of Human Sciences > Institute of Psychology
UniBE Contributor:	Ruch, Simon, Züst, Marc, Henke, Katharina
Subjects:	100 Philosophy > 150 Psychology
Series:	bioRxiv
Publisher:	Cold Spring Harbor Laboratory
Funders:	[UNSPECIFIED] Interfaculty Research Cooperation grant “Decoding Sleep: From Neurons to Health and Mind” ; [4] Swiss National Science Foundation
Language:	English
Submitter:	Simon Ruch
Date Deposited:	31 Jul 2020 16:19
Last Modified:	05 Dec 2022 15:39
Publisher DOI:	10.1101/2020.07.16.206482
URI:	https://boris.unibe.ch/id/eprint/145491