Bacterial toxins in musculoskeletal infections.

Saeed, Kordo; Sendi, Parham; Arnold, William V; Bauer, Thomas W; Coraça-Huber, Débora C; Chen, Antonia F; Choe, Hyonmin; Daiss, John L; Ghert, Michelle; Hickok, Noreen J; Nishitani, Kohei; Springer, Bryan D; Stoodley, Paul; Sculco, Thomas P; Brause, Barry D; Parvizi, Javad; McLaren, Alex C; Schwarz, Edward M (2020). Bacterial toxins in musculoskeletal infections. (In Press). Journal of orthopaedic research Wiley 10.1002/jor.24683

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Musculoskeletal infections (MSKIs) remain a major health burden in orthopaedics. Bacterial toxins are foundational to pathogenesis in MSKI, but poorly understood by the community of providers that care for patients with MSKI, inducing an international group of microbiologists, infectious diseases specialists, orthopaedic surgeons and biofilm scientists to review the literature in this field to identify key topics and compile the current knowledge on the role of toxins in MSKI, with the goal of illuminating potential impact on biofilm formation and dispersal as well as therapeutic strategies. The group concluded that further research is needed to maximize our understanding of the effect of toxins on MSKIs, including: (i) further research to identify the roles of bacterial toxins in MSKIs, (ii) establish the understanding of the importance of environmental and host factors and in vivo expression of toxins throughout the course of an infection, (iii) establish the principles of drug-ability of antitoxins as antimicrobial agents in MSKIs, (iv) have well-defined metrics of success for antitoxins as antiinfective drugs, (v) design a cocktail of antitoxins against specific pathogens to (a) inhibit biofilm formation and (b) inhibit toxin release. The applicability of antitoxins as potential antimicrobials in the era of rising antibiotic resistance could meet the needs of day-to-day clinicians.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

UniBE Contributor:

Sendi, Parham

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0736-0266

Publisher:

Wiley

Language:

English

Submitter:

Parham Sendi

Date Deposited:

17 Aug 2020 10:49

Last Modified:

17 Aug 2020 10:49

Publisher DOI:

10.1002/jor.24683

PubMed ID:

32255540

Uncontrolled Keywords:

PJI Staphylococcus bacterial toxins biofilm meeting musculoskeletal infection (MSKI) virulence factors

URI:

https://boris.unibe.ch/id/eprint/145935

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