Molecular modulation of autophagy: New venture to target resistant cancer stem cells.

Mandhair, Harpreet K.; Arambasic, Miroslav; Novak, Urban; Radpour, Ramin (2020). Molecular modulation of autophagy: New venture to target resistant cancer stem cells. World journal of stem cells, 12(5), pp. 303-322. 10.4252/wjsc.v12.i5.303

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Autophagy is a highly regulated catabolic process in which superfluous, damaged organelles and other cytoplasmic constituents are delivered to the lysosome for clearance and the generation of macromolecule substrates during basal or stressed conditions. Autophagy is a bimodal process with a context dependent role in the initiation and the development of cancers. For instance, autophagy provides an adaptive response to cancer stem cells to survive metabolic stresses, by influencing disease propagation via modulation of essential signaling pathways or by promoting resistance to chemotherapeutics. Autophagy has been implicated in a cross talk with apoptosis. Understanding the complex interactions provides an opportunity to improve cancer therapy and the clinical outcome for the cancer patients. In this review, we provide a comprehensive view on the current knowledge on autophagy and its role in cancer cells with a particular focus on cancer stem cell homeostasis.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology

UniBE Contributor:

Mandhair, Harpreet Kaur; Arambasic, Miroslav; Novak, Urban and Radpour, Ramin

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1948-0210

Language:

English

Submitter:

Rebeka Gerber

Date Deposited:

24 Aug 2020 14:40

Last Modified:

24 Aug 2020 14:40

Publisher DOI:

10.4252/wjsc.v12.i5.303

PubMed ID:

32547680

Uncontrolled Keywords:

Autophagy Cancer cells Cancer metastasis Cancer stem cells Cancer therapy Therapeutic resistance

BORIS DOI:

10.7892/boris.146001

URI:

https://boris.unibe.ch/id/eprint/146001

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