Mandhair, Harpreet K.; Arambasic, Miroslav; Novak, Urban; Radpour, Ramin (2020). Molecular modulation of autophagy: New venture to target resistant cancer stem cells. World journal of stem cells, 12(5), pp. 303-322. 10.4252/wjsc.v12.i5.303
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Autophagy is a highly regulated catabolic process in which superfluous, damaged organelles and other cytoplasmic constituents are delivered to the lysosome for clearance and the generation of macromolecule substrates during basal or stressed conditions. Autophagy is a bimodal process with a context dependent role in the initiation and the development of cancers. For instance, autophagy provides an adaptive response to cancer stem cells to survive metabolic stresses, by influencing disease propagation via modulation of essential signaling pathways or by promoting resistance to chemotherapeutics. Autophagy has been implicated in a cross talk with apoptosis. Understanding the complex interactions provides an opportunity to improve cancer therapy and the clinical outcome for the cancer patients. In this review, we provide a comprehensive view on the current knowledge on autophagy and its role in cancer cells with a particular focus on cancer stem cell homeostasis.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology |
UniBE Contributor: |
Mandhair, Harpreet Kaur, Arambasic, Miroslav, Novak, Urban, Radpour, Ramin |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1948-0210 |
Language: |
English |
Submitter: |
Rebeka Gerber |
Date Deposited: |
24 Aug 2020 14:40 |
Last Modified: |
29 Jan 2023 14:01 |
Publisher DOI: |
10.4252/wjsc.v12.i5.303 |
PubMed ID: |
32547680 |
Uncontrolled Keywords: |
Autophagy Cancer cells Cancer metastasis Cancer stem cells Cancer therapy Therapeutic resistance |
BORIS DOI: |
10.7892/boris.146001 |
URI: |
https://boris.unibe.ch/id/eprint/146001 |
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