Dufour, Jean-François; Caussy, Cyrielle; Loomba, Rohit (2020). Combination therapy for non-alcoholic steatohepatitis: rationale, opportunities and challenges. Gut, 69(10), pp. 1877-1884. BMJ Publishing Group 10.1136/gutjnl-2019-319104
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Non-alcoholic steatohepatitis (NASH) is becoming a leading cause of cirrhosis with the burden of NASH-related complications projected to increase massively over the coming years. Several molecules with different mechanisms of action are currently in development to treat NASH, although reported efficacy to date has been limited. Given the complexity of the pathophysiology of NASH, it will take the engagement of several targets and pathways to improve the results of pharmacological intervention, which provides a rationale for combination therapies in the treatment of NASH. As the field is moving towards combination therapy, this article reviews the rationale for such combination therapies to treat NASH based on the current therapeutic landscape as well as the advantages and limitations of this approach.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie |
UniBE Contributor: |
Dufour, Jean-François |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0017-5749 |
Publisher: |
BMJ Publishing Group |
Language: |
English |
Submitter: |
Thi Thao Anh Pham |
Date Deposited: |
08 Dec 2020 08:49 |
Last Modified: |
05 Dec 2022 15:40 |
Publisher DOI: |
10.1136/gutjnl-2019-319104 |
PubMed ID: |
32381514 |
Uncontrolled Keywords: |
hepatobiliary disease liver nonalcoholic steatohepatitis |
BORIS DOI: |
10.7892/boris.146468 |
URI: |
https://boris.unibe.ch/id/eprint/146468 |
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