Combination therapy for non-alcoholic steatohepatitis: rationale, opportunities and challenges.

Dufour, Jean-François; Caussy, Cyrielle; Loomba, Rohit (2020). Combination therapy for non-alcoholic steatohepatitis: rationale, opportunities and challenges. Gut, 69(10), pp. 1877-1884. BMJ Publishing Group 10.1136/gutjnl-2019-319104

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Non-alcoholic steatohepatitis (NASH) is becoming a leading cause of cirrhosis with the burden of NASH-related complications projected to increase massively over the coming years. Several molecules with different mechanisms of action are currently in development to treat NASH, although reported efficacy to date has been limited. Given the complexity of the pathophysiology of NASH, it will take the engagement of several targets and pathways to improve the results of pharmacological intervention, which provides a rationale for combination therapies in the treatment of NASH. As the field is moving towards combination therapy, this article reviews the rationale for such combination therapies to treat NASH based on the current therapeutic landscape as well as the advantages and limitations of this approach.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie

UniBE Contributor:

Dufour, Jean-François

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0017-5749

Publisher:

BMJ Publishing Group

Language:

English

Submitter:

Thi Thao Anh Pham

Date Deposited:

08 Dec 2020 08:49

Last Modified:

30 Mar 2021 09:20

Publisher DOI:

10.1136/gutjnl-2019-319104

PubMed ID:

32381514

Uncontrolled Keywords:

hepatobiliary disease liver nonalcoholic steatohepatitis

BORIS DOI:

10.7892/boris.146468

URI:

https://boris.unibe.ch/id/eprint/146468

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