Looking back: A short history of the discovery of enzymes and how they became powerful chemical tools

Heckmann, Christian M.; Paradisi, Francesca (2020). Looking back: A short history of the discovery of enzymes and how they became powerful chemical tools. ChemCatChem, 12(24), pp. 6082-6102. WILEY-VCH 10.1002/cctc.202001107

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Enzymatic approaches to challenges in chemical synthesis are increasingly popular and very attractive to industry given their green nature and high efficiency compared to traditional methods. In this historical review we highlight the developments across several fields that were necessary to create the modern field of biocatalysis, with enzyme engineering and directed evolution at its core. We exemplify the modular, incremental, and highly unpredictable nature of scientific discovery, driven by curiosity, and showcase the resulting examples of cutting-edge enzymatic applications in industry.

Item Type:

Journal Article (Review Article)

Division/Institute:

08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP)

UniBE Contributor:

Paradisi, Francesca

Subjects:

500 Science > 540 Chemistry

ISSN:

1867-3880

Publisher:

WILEY-VCH

Funders:

[UNSPECIFIED] Biotechnology and Biological Sciences Research Council

Language:

English

Submitter:

Francesca Paradisi

Date Deposited:

03 Feb 2021 14:26

Last Modified:

03 Feb 2021 14:26

Publisher DOI:

10.1002/cctc.202001107

BORIS DOI:

10.48350/146601

URI:

https://boris.unibe.ch/id/eprint/146601

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