Effects of additional collagen in biphasic calcium phosphates: a study in a rabbit calvaria.

Schaller, Benoît; Fujioka-Kobayashi, Masako; Zihlmann, Claudio; Schuler, Viola Christina; Katagiri, Hiroki; Lang, Niklaus P.; Saulacic, Nikola (2020). Effects of additional collagen in biphasic calcium phosphates: a study in a rabbit calvaria. Clinical oral investigations, 24(9), pp. 3093-3103. Springer-Verlag 10.1007/s00784-019-03181-8

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OBJECTIVES

Biphasic calcium phosphates (BCP) are synthetic biomaterials developed as an alternative to the autogenous bone grafts and xenografts. The aim of the present study was to assess the influence of the addition of collagen onto the BCP resorption rate and bone formation.

MATERIAL AND METHODS

Eighteen male NWZ rabbits approximately 12 weeks of age were used. Critical size defects were randomly treated with bilayered BCP materials comprising 12% HA and 88% α-TCP with and without collagen or sham-operated, respectively. All defects were covered with a resorbable collagen membrane. Animals were euthanized after 3 and 12 weeks of healing and investigated by micro-CT, histologic, and histomorphometric analysis.

RESULTS

Woven bone formation was observed from the original bone at 3-week healing in all samples. After 3 months, mainly lamellar new bone in the peripheral area was observed. In the central region, both woven and lamellar bone were seen. Samples containing collagen showed less residual biomaterial than without collagen at both healing periods. Both types of granules were in close contact with new bone, yielding a complete defect closure at 3 months of healing. However, new bone volume and area was similar for both biomaterials.

CONCLUSIONS

Within its limitations, the study results qualify collagen as a biocompatible carrier for BCPs. The presence of collagen indicated neither significant impact on the resorption of the BCPs nor on bone formation.

CLINICAL RELEVANCE

The addition of collagen to BCPs might not be beneficial for the augmentation of extended bone deficiencies.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Craniomaxillofacial Surgery

UniBE Contributor:

Schaller, Benoît; Kobayashi, Masako; Katagiri, Hiroki and Saulacic, Nikola

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1432-6981

Publisher:

Springer-Verlag

Language:

English

Submitter:

Caroline Dominique Zürcher

Date Deposited:

07 Oct 2020 17:28

Last Modified:

07 Oct 2020 17:30

Publisher DOI:

10.1007/s00784-019-03181-8

PubMed ID:

31953682

Uncontrolled Keywords:

Animal experiments Biomaterials Bone regeneration Bone substitutes Guided tissue regeneration Morphometric analysis

BORIS DOI:

10.7892/boris.146829

URI:

https://boris.unibe.ch/id/eprint/146829

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