Schaller, Benoît; Fujioka-Kobayashi, Masako; Zihlmann, Claudio; Schuler, Viola Christina; Katagiri, Hiroki; Lang, Niklaus P.; Saulacic, Nikola (2020). Effects of additional collagen in biphasic calcium phosphates: a study in a rabbit calvaria. Clinical oral investigations, 24(9), pp. 3093-3103. Springer-Verlag 10.1007/s00784-019-03181-8
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OBJECTIVES
Biphasic calcium phosphates (BCP) are synthetic biomaterials developed as an alternative to the autogenous bone grafts and xenografts. The aim of the present study was to assess the influence of the addition of collagen onto the BCP resorption rate and bone formation.
MATERIAL AND METHODS
Eighteen male NWZ rabbits approximately 12 weeks of age were used. Critical size defects were randomly treated with bilayered BCP materials comprising 12% HA and 88% α-TCP with and without collagen or sham-operated, respectively. All defects were covered with a resorbable collagen membrane. Animals were euthanized after 3 and 12 weeks of healing and investigated by micro-CT, histologic, and histomorphometric analysis.
RESULTS
Woven bone formation was observed from the original bone at 3-week healing in all samples. After 3 months, mainly lamellar new bone in the peripheral area was observed. In the central region, both woven and lamellar bone were seen. Samples containing collagen showed less residual biomaterial than without collagen at both healing periods. Both types of granules were in close contact with new bone, yielding a complete defect closure at 3 months of healing. However, new bone volume and area was similar for both biomaterials.
CONCLUSIONS
Within its limitations, the study results qualify collagen as a biocompatible carrier for BCPs. The presence of collagen indicated neither significant impact on the resorption of the BCPs nor on bone formation.
CLINICAL RELEVANCE
The addition of collagen to BCPs might not be beneficial for the augmentation of extended bone deficiencies.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Craniomaxillofacial Surgery |
UniBE Contributor: |
Schaller, Benoît, Kobayashi, Masako (B), Katagiri, Hiroki, Saulacic, Nikola |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1432-6981 |
Publisher: |
Springer-Verlag |
Language: |
English |
Submitter: |
Caroline Dominique Zürcher |
Date Deposited: |
07 Oct 2020 17:28 |
Last Modified: |
19 Jan 2024 00:25 |
Publisher DOI: |
10.1007/s00784-019-03181-8 |
PubMed ID: |
31953682 |
Uncontrolled Keywords: |
Animal experiments Biomaterials Bone regeneration Bone substitutes Guided tissue regeneration Morphometric analysis |
BORIS DOI: |
10.7892/boris.146829 |
URI: |
https://boris.unibe.ch/id/eprint/146829 |
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