Dilation Modifies Association Between Symptoms and Esophageal Eosinophilia in Adult Patients With Eosinophilic Esophagitis.

Safroneeva, Ekaterina; Cotton, Cary C; Schoepfer, Alain M; Zwahlen, Marcel; Woosley, John T; Dellon, Evan S (2020). Dilation Modifies Association Between Symptoms and Esophageal Eosinophilia in Adult Patients With Eosinophilic Esophagitis. American journal of gastroenterology, 115(12), pp. 2098-2102. Nature 10.14309/ajg.0000000000000957

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INTRODUCTION

We investigated whether dilation modifies the association between symptoms and esophageal eosinophilia (peak esophageal eosinophils/high-power field [eos/hpf]) in patients with eosinophilic esophagitis enrolled into a randomized trial comparing the efficacy of budesonide and fluticasone.

METHODS

Baseline Dysphagia Symptom Questionnaire and Eosinophilic Esophagitis Activity Index were available in 102 and 73 patients, respectively, of whom 56 and 39 underwent dilation at screening endoscopy before symptom assessment. The pair-wise relationship between Dysphagia Symptom Questionnaire, Eosinophilic Esophagitis Activity Index, and eos/hpf was analyzed with nonparametric correlations.

RESULTS

In nondilated patients, the association between baseline eos/hpf and symptoms was moderate and significant, although it was abolished in dilated patients.

DISCUSSION

Dilation modifies association between symptoms and eos/hpf (clinicaltrials.gov NCT02019758).

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)

UniBE Contributor:

Safroneeva, Ekaterina and Zwahlen, Marcel

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

0002-9270

Publisher:

Nature

Language:

English

Submitter:

Andrea Flükiger-Flückiger

Date Deposited:

15 Oct 2020 19:54

Last Modified:

05 Jan 2021 19:53

Publisher DOI:

10.14309/ajg.0000000000000957

PubMed ID:

33009060

BORIS DOI:

10.7892/boris.146858

URI:

https://boris.unibe.ch/id/eprint/146858

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