Safroneeva, Ekaterina; Cotton, Cary C; Schoepfer, Alain M; Zwahlen, Marcel; Woosley, John T; Dellon, Evan S (2020). Dilation Modifies Association Between Symptoms and Esophageal Eosinophilia in Adult Patients With Eosinophilic Esophagitis. American journal of gastroenterology, 115(12), pp. 2098-2102. Nature 10.14309/ajg.0000000000000957
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INTRODUCTION
We investigated whether dilation modifies the association between symptoms and esophageal eosinophilia (peak esophageal eosinophils/high-power field [eos/hpf]) in patients with eosinophilic esophagitis enrolled into a randomized trial comparing the efficacy of budesonide and fluticasone.
METHODS
Baseline Dysphagia Symptom Questionnaire and Eosinophilic Esophagitis Activity Index were available in 102 and 73 patients, respectively, of whom 56 and 39 underwent dilation at screening endoscopy before symptom assessment. The pair-wise relationship between Dysphagia Symptom Questionnaire, Eosinophilic Esophagitis Activity Index, and eos/hpf was analyzed with nonparametric correlations.
RESULTS
In nondilated patients, the association between baseline eos/hpf and symptoms was moderate and significant, although it was abolished in dilated patients.
DISCUSSION
Dilation modifies association between symptoms and eos/hpf (clinicaltrials.gov NCT02019758).
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM) |
UniBE Contributor: |
Safroneeva, Ekaterina, Zwahlen, Marcel |
Subjects: |
600 Technology > 610 Medicine & health 300 Social sciences, sociology & anthropology > 360 Social problems & social services |
ISSN: |
0002-9270 |
Publisher: |
Nature |
Language: |
English |
Submitter: |
Andrea Flükiger-Flückiger |
Date Deposited: |
15 Oct 2020 19:54 |
Last Modified: |
05 Dec 2022 15:40 |
Publisher DOI: |
10.14309/ajg.0000000000000957 |
PubMed ID: |
33009060 |
BORIS DOI: |
10.7892/boris.146858 |
URI: |
https://boris.unibe.ch/id/eprint/146858 |
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