Cerebrospinal fluid lactate in dogs with inflammatory central nervous system disorders.

Mariani, Christopher L.; Nye, Carolyn J.; Tokarz, Debra A.; Green, Lauren; Lau, Jeanie; Zidan, Natalia; Early, Peter J.; Guevar, Julien; Muñana, Karen R.; Olby, Natasha J.; Miles, Sarita (2019). Cerebrospinal fluid lactate in dogs with inflammatory central nervous system disorders. Journal of veterinary internal medicine, 33(6), pp. 2701-2708. Wiley-Blackwell 10.1111/jvim.15606

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BACKGROUND

Cerebrospinal fluid (CSF) lactate is frequently used as a biomarker in humans with inflammatory central nervous system (CNS) disorders including bacterial meningitis and autoimmune disorders such as multiple sclerosis.

HYPOTHESIS

Cerebrospinal fluid lactate concentrations are increased in a subset of dogs with inflammatory CNS disorders.

ANIMALS

One hundred two client-owned dogs diagnosed with inflammatory CNS disease.

METHODS

Case series. Cases were identified both prospectively at the time of diagnosis and retrospectively by review of a CSF biorepository. Cerebrospinal fluid lactate was analyzed with a commercially available, handheld lactate monitor. Subcategories of inflammatory disease were created for comparison (eg, steroid-responsive meningitis arteritis, meningoencephalitis of unknown etiology).

RESULTS

Cerebrospinal fluid lactate concentrations were above reference range in 47% of dogs (median, 2.5 mmol/L; range, 1.0-11.7 mmol/L). There was no significant difference in lactate concentrations between disease subcategories (P = .48). Significant but weak correlations were noted between CSF lactate concentration and nucleated cell count (r = .33, P < .001), absolute large mononuclear cell count (r = .44, P < .001), absolute small mononuclear cell count (r = .39, P < .001), absolute neutrophil cell count (r = .24, P = .01), and protein (r = .44, P < .001). No correlation was found between CSF lactate concentration and CSF red blood cell count (P = .58). There was no significant association of CSF lactate concentration with survival (P = .27).

CONCLUSIONS AND CLINICAL IMPORTANCE

Cerebrospinal fluid lactate concentrations could serve as a rapid biomarker of inflammatory CNS disease in dogs.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Clinical Neurology
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV)

UniBE Contributor:

Guevar, Julien Jean

Subjects:

600 Technology > 630 Agriculture

ISSN:

0891-6640

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Monika Mumenthaler

Date Deposited:

28 Oct 2020 14:52

Last Modified:

28 Oct 2020 15:01

Publisher DOI:

10.1111/jvim.15606

PubMed ID:

31549740

Uncontrolled Keywords:

canine encephalitis meningitis meningo meningoencephalitis myelitis

BORIS DOI:

10.7892/boris.147097

URI:

https://boris.unibe.ch/id/eprint/147097

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