Mariani, Christopher L.; Nye, Carolyn J.; Tokarz, Debra A.; Green, Lauren; Lau, Jeanie; Zidan, Natalia; Early, Peter J.; Guevar, Julien; Muñana, Karen R.; Olby, Natasha J.; Miles, Sarita (2019). Cerebrospinal fluid lactate in dogs with inflammatory central nervous system disorders. Journal of veterinary internal medicine, 33(6), pp. 2701-2708. Wiley-Blackwell 10.1111/jvim.15606
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BACKGROUND
Cerebrospinal fluid (CSF) lactate is frequently used as a biomarker in humans with inflammatory central nervous system (CNS) disorders including bacterial meningitis and autoimmune disorders such as multiple sclerosis.
HYPOTHESIS
Cerebrospinal fluid lactate concentrations are increased in a subset of dogs with inflammatory CNS disorders.
ANIMALS
One hundred two client-owned dogs diagnosed with inflammatory CNS disease.
METHODS
Case series. Cases were identified both prospectively at the time of diagnosis and retrospectively by review of a CSF biorepository. Cerebrospinal fluid lactate was analyzed with a commercially available, handheld lactate monitor. Subcategories of inflammatory disease were created for comparison (eg, steroid-responsive meningitis arteritis, meningoencephalitis of unknown etiology).
RESULTS
Cerebrospinal fluid lactate concentrations were above reference range in 47% of dogs (median, 2.5 mmol/L; range, 1.0-11.7 mmol/L). There was no significant difference in lactate concentrations between disease subcategories (P = .48). Significant but weak correlations were noted between CSF lactate concentration and nucleated cell count (r = .33, P < .001), absolute large mononuclear cell count (r = .44, P < .001), absolute small mononuclear cell count (r = .39, P < .001), absolute neutrophil cell count (r = .24, P = .01), and protein (r = .44, P < .001). No correlation was found between CSF lactate concentration and CSF red blood cell count (P = .58). There was no significant association of CSF lactate concentration with survival (P = .27).
CONCLUSIONS AND CLINICAL IMPORTANCE
Cerebrospinal fluid lactate concentrations could serve as a rapid biomarker of inflammatory CNS disease in dogs.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Clinical Neurology 05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) |
UniBE Contributor: |
Guevar, Julien Jean |
Subjects: |
600 Technology > 630 Agriculture |
ISSN: |
0891-6640 |
Publisher: |
Wiley-Blackwell |
Language: |
English |
Submitter: |
Barbara Bach |
Date Deposited: |
28 Oct 2020 14:52 |
Last Modified: |
05 Dec 2022 15:41 |
Publisher DOI: |
10.1111/jvim.15606 |
PubMed ID: |
31549740 |
Uncontrolled Keywords: |
canine encephalitis meningitis meningo meningoencephalitis myelitis |
BORIS DOI: |
10.7892/boris.147097 |
URI: |
https://boris.unibe.ch/id/eprint/147097 |
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