Validation of high bleeding risk criteria and definition as proposed by the academic research consortium for high bleeding risk.

Corpataux, Noé; Spirito, Alessandro; Gragnano, Felice; Vaisnora, Lukas; Galea, Roberto; Svab, Stefano; Gargiulo, Giuseppe; Zanchin, Thomas; Zanchin, Christian; Siontis, George C M; Praz, Fabien; Lanz, Jonas; Hunziker, Lukas; Stortecky, Stefan; Pilgrim, Thomas; Räber, Lorenz; Capodanno, Davide; Urban, Philip; Pocock, Stuart; Heg, Dik; ... (2020). Validation of high bleeding risk criteria and definition as proposed by the academic research consortium for high bleeding risk. European Heart Journal, 41(38), pp. 3743-3749. Oxford University Press 10.1093/eurheartj/ehaa671

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AIMS

To validate the set of clinical and biochemical criteria proposed by consensus by the Academic Research Consortium (ARC) for High Bleeding Risk (HBR) for the identification of HBR patients. These criteria were categorized into major and minor, if expected to carry in isolation, respectively, ≥4% and <4% Bleeding Academic Research Consortium (BARC) 3 or 5 bleeding risk within 1-year after percutaneous coronary intervention (PCI). High bleeding risk patients are those meeting at least 1 major or 2 minor criteria.

METHODS AND RESULTS

All patients undergoing PCI at Bern University Hospital, between February 2009 and September 2018 were prospectively entered into the Bern PCI Registry (NCT02241291). Age, haemoglobin, platelet count, creatinine, and use of oral anticoagulation were prospectively collected, while the remaining HBR criteria except for planned surgery were retrospectively adjudicated. A total of 16 580 participants with complete ARC-HBR criteria were included. After assigning 1 point to each major and 0.5 point to each minor criterion, we observed for every 0.5 score increase a step-wise augmentation of BARC 3 or 5 bleeding rates at 1 year ranging from 1.90% among patients fulfilling no criterion, through 4.01%, 5.98%, 7.42%, 8.60%, 12.21%, 12.29%, and 17.64%. All major and five out of six minor criteria, conferred in isolation a risk for BARC 3 or 5 bleeding at 1 year exceeding 4% at the upper limit of the 95% confidence intervals.

CONCLUSION

All major and the majority of minor ARC-HBR criteria identify in isolation patients at HBR.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic of Intensive Care
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
04 Faculty of Medicine > Pre-clinic Human Medicine > CTU Bern
04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine

UniBE Contributor:

Corpataux, Noé Emile; Spirito, Alessandro; Vaisnora, Lukas; Galea, Roberto; Svab, Stefano; Zanchin, Thomas; Zanchin, Christian; Siontis, Georgios; Praz, Fabien; Lanz, Jonas; Hunziker Munsch, Lukas Christoph; Stortecky, Stefan; Pilgrim, Thomas; Räber, Lorenz; Heg, Dierik Hans; Windecker, Stephan and Valgimigli, Marco

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0195-668X

Publisher:

Oxford University Press

Language:

English

Submitter:

Nadia Biscozzo

Date Deposited:

27 Oct 2020 18:21

Last Modified:

28 Oct 2020 09:21

Publisher DOI:

10.1093/eurheartj/ehaa671

PubMed ID:

33029615

Uncontrolled Keywords:

Academic Research Consortium Bleeding Percutaneous coronary intervention Validation

BORIS DOI:

10.7892/boris.147517

URI:

https://boris.unibe.ch/id/eprint/147517

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