Pharmacokinetics of Faster and Standard Insulin Aspart During Fully Closed-Loop Insulin Delivery in Type 2 Diabetes.

Herzig, David; Dehais, Joachim; Prost, Jean-Christophe; Nakas, Christos T.; Stettler, Christoph; Bally, Lia; Hovorka, Roman (2020). Pharmacokinetics of Faster and Standard Insulin Aspart During Fully Closed-Loop Insulin Delivery in Type 2 Diabetes. Diabetes technology & therapeutics, 22(9), pp. 691-696. Mary Ann Liebert 10.1089/dia.2019.0477

[img] Text
Parmacokinetics of faster and standard.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (238kB) | Request a copy

Background:
Faster insulin aspart is a novel formulation of insulin aspart aiming to accelerate its subcutaneous absorption. The aim of this study was to compare pharmacokinetics of faster insulin aspart versus standard insulin aspart in adults with type 2 diabetes during closed-loop insulin delivery.
Methods:
We assessed the pharmacokinetics of faster and standard insulin aspart from data obtained in a randomized double-blind crossover study evaluating fully closed-loop insulin delivery in adults with type 2 diabetes (n = 13, age 59 ± 10 years, BMI 34.5 ± 9.1 kg/m2, HbA1c 7.7% ± 1.2% [60 ± 13 mmol/mol]). Blood samples were collected every 15-30 min for 10 h to determine plasma insulin aspart concentration using liquid chromatography mass spectrometry. Time to peak plasma concentration (Tmax) was calculated using a two-compartment model.
Results:
Tmax was 68.7 ± 21.6 min for faster aspart and 89.7 ± 31.8 min for aspart (mean paired difference faster aspart minus aspart -15.5 min, 95% CI [-31.6 to 0.6 min], P = 0.06). Metabolic clearance rate did not differ between the two insulins (P = 0.61). Insulin amount delivered during closed-loop with faster aspart positively correlated with Tmax (rS = 0.73, P = 0.01), whereas no statistically significant correlation was found with body mass index (BMI), weight or HbA1C (all P > 0.18).
Conclusion:
In conclusion, Tmax tended to be shorter for faster aspart versus aspart during fully automated closed-loop insulin delivery and positively correlated with the amount of insulin delivered.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Institute of Clinical Chemistry

UniBE Contributor:

Herzig, David; Dehais, Joachim Blaise; Prost, Jean-Christophe; Nakas, Christos T.; Stettler, Christoph and Bally, Lia Claudia

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1520-9156

Publisher:

Mary Ann Liebert

Language:

English

Submitter:

Karin Balmer

Date Deposited:

09 Nov 2020 14:12

Last Modified:

09 Nov 2020 14:12

Publisher DOI:

10.1089/dia.2019.0477

PubMed ID:

31999478

Uncontrolled Keywords:

Closed-loop insulin delivery Faster insulin aspart Pharmacokinetics Type 2 diabetes

BORIS DOI:

10.7892/boris.147768

URI:

https://boris.unibe.ch/id/eprint/147768

Actions (login required)

Edit item Edit item
Provide Feedback