Significance of tumour regression in lymph node metastases of gastric and gastro-oesophageal junction adenocarcinomas.

Reim, Daniel; Novotny, Alexander; Friess, Helmut; Slotta-Huspenina, Julia; Weichert, Wilko; Ott, Katja; Dislich, Bastian; Lorenzen, Sylvie; Becker, Karen; Langer, Rupert (2020). Significance of tumour regression in lymph node metastases of gastric and gastro-oesophageal junction adenocarcinomas. The journal of pathology: clinical research, 6(4), pp. 263-272. Wiley 10.1002/cjp2.169

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The presence of lymph node (LN) metastases is one of the most important negative prognostic factors in upper gastrointestinal carcinomas. Tumour regression similar to that in primary tumours can be observed in LN metastases after neoadjuvant therapy. We evaluated the prognostic impact of histological regression in LNs in 480 adenocarcinomas of the stomach and gastro-oesophageal junction after neoadjuvant chemotherapy. Regressive changes in LNs (nodular and/or hyaline fibrosis, sheets of foamy histiocytes or acellular mucin) were assessed by histology. In total, regressive changes were observed in 128 of 480 patients. LNs were categorised according to the absence or presence of both residual tumour and regressive changes (LN-/+ and Reg-/+). 139 cases were LN-/Reg-, 28 cases without viable LN metastases revealed regressive changes (LN-/Reg+), 100 of 313 cases with LN metastases showed regressive changes (LN+/Reg+), and 213 of 313 metastatic LN had no signs of regression (LN+/Reg-). Overall, LN/Reg categorisation correlated with overall survival with the best prognosis for LN-/Reg- and the worst prognosis for LN+/Reg- (p < 0.001). LN-/Reg+ cases had a nearly significant better outcome than LN+/Reg+ (p = 0.054) and the latter had a significantly better prognosis than LN+/Reg- (p = 0.01). The LN/Reg categorisation was also an independent prognostic factor in multivariate analysis (HR = 1.23; 95% CI 1.1-1.38; p < 0.001). We conclude that the presence of regressive changes after neoadjuvant treatment in LNs and LN metastases of gastric and gastro-oesophageal junction cancers is a relevant prognostic factor.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Dislich, Bastian and Langer, Rupert

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

2056-4538

Publisher:

Wiley

Language:

English

Submitter:

Bastian Dislich

Date Deposited:

12 Nov 2020 11:47

Last Modified:

12 Nov 2020 11:47

Publisher DOI:

10.1002/cjp2.169

PubMed ID:

32401432

Uncontrolled Keywords:

gastric cancer lymph nodes neoadjuvant chemotherapy tumour regression

BORIS DOI:

10.7892/boris.147839

URI:

https://boris.unibe.ch/id/eprint/147839

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