Favourable long-term survival of patients with esophageal cancer treated with extended transhiatal esophagectomy combined with en bloc lymphadenectomy: results from a retrospective observational cohort study.

Kröll, Dino; Borbély, Yves Michael; Dislich, Bastian; Haltmeier, Tobias; Malinka, Thomas; Biebl, Matthias; Langer, Rupert; Candinas, Daniel; Seiler, Christian (2020). Favourable long-term survival of patients with esophageal cancer treated with extended transhiatal esophagectomy combined with en bloc lymphadenectomy: results from a retrospective observational cohort study. BMC surgery, 20(1), p. 197. BioMed Central 10.1186/s12893-020-00855-z

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BACKGROUND

Although considered complex and challenging, esophagectomy remains the best potentially curable treatment option for resectable esophageal and esophagogastric junction (AEG) carcinomas. The optimal surgical approach and technique as well as the extent of lymphadenectomy, particularly regarding quality of life and short- and long-term outcomes, are still a matter of debate. To lower perioperative morbidity, we combined the advantages of a one-cavity approach with extended lymph node dissection (usually achieved by only a two-cavity approach) and developed a modified single-cavity transhiatal approach for esophagectomy.

METHODS

The aim of this study was to evaluate the outcome of an extended transhiatal esophageal resection with radical bilateral mediastinal en bloc lymphadenectomy (eTHE). A prospective database of 166 patients with resectable cancers of the esophagus (including adenocarcinomas of the AEG types I and II) were analyzed. Patients were treated between 2001 and 2017 with eTHE at a tertiary care university center. Relevant patient characteristics and outcome parameters were collected and analyzed. The primary endpoint was 5-year overall survival. Secondary outcomes included short-term morbidity, mortality, radicalness of en bloc resection and oncologic efficacy.

RESULTS

The overall survival rates at 1, 3 and 5 years were 84, 70, and 61.0%, respectively. The in-hospital mortality rate after eTHE was 1.2%. Complications with a Clavien-Dindo score of III/IV occurred in 31 cases (18.6%). A total of 25 patients (15.1%) had a major pulmonary complication. The median hospital stay was 17 days (interquartile range (IQR) 12). Most patients (n = 144; 86.7%) received neoadjuvant treatment. The median number of lymph nodes resected was 25 (IQR 17). The R0 resection rate was 97%.

CONCLUSION

In patients with esophageal cancer, eTHE without thoracotomy resulted in excellent long-term survival, an above average number of resected lymph nodes and an acceptable postoperative morbidity and mortality.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine
04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Kröll, Dino; Borbély, Yves Michael; Dislich, Bastian; Haltmeier, Tobias; Langer, Rupert; Candinas, Daniel and Seiler, Christian A.

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology

ISSN:

1471-2482

Publisher:

BioMed Central

Language:

English

Submitter:

Bastian Dislich

Date Deposited:

12 Nov 2020 11:52

Last Modified:

11 Mar 2021 02:42

Publisher DOI:

10.1186/s12893-020-00855-z

PubMed ID:

32917177

Uncontrolled Keywords:

En bloc lymphadenectomy Esophageal cancer Extended transhiatal esophagectomy Long-term survival Short-term outcome

BORIS DOI:

10.7892/boris.147840

URI:

https://boris.unibe.ch/id/eprint/147840

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