Medical management of metabolic and cardiovascular complications after liver transplantation.

Becchetti, Chiara; Dirchwolf, Melisa; Banz Wüthrich, Vanessa; Dufour, Jean-François (2020). Medical management of metabolic and cardiovascular complications after liver transplantation. World journal of gastroenterology, 26(18), pp. 2138-2154. WJG Press 10.3748/wjg.v26.i18.2138

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Liver transplantation represents the only curative option for patients with end-stage liver disease, fulminant hepatitis and advanced hepatocellular carcinoma. Even though major advances in transplantation in the last decades have achieved excellent survival rates in the early post-transplantation period, long-term survival is hampered by the lack of improvement in survival in the late post transplantation period (over 5 years after transplantation). The main etiologies for late mortality are malignancies and cardiovascular complications. The latter are increasingly prevalent in liver transplant recipients due to the development or worsening of metabolic syndrome and all its components (arterial hypertension, dyslipidemia, obesity, renal injury, etc.). These comorbidities result from a combination of pre-liver transplant features, immunosuppressive agent side-effects, changes in metabolism and hemodynamics after liver transplantation and the adoption of a sedentary lifestyle. In this review we describe the most prevalent metabolic and cardiovascular complications present after liver transplantation, as well as proposing management strategies.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Viszeralchirurgie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Viszeralchirurgie

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine

UniBE Contributor:

Becchetti, Chiara; Banz Wüthrich, Vanessa and Dufour, Jean-François

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1007-9327

Publisher:

WJG Press

Language:

English

Submitter:

Thi Thao Anh Pham

Date Deposited:

09 Dec 2020 08:27

Last Modified:

09 Dec 2020 08:27

Publisher DOI:

10.3748/wjg.v26.i18.2138

PubMed ID:

32476781

Uncontrolled Keywords:

Hypertension New-onset diabetes after transplantation Obesity Orthotopic liver transplantation Post-transplantation metabolic syndrome Solid organ transplantation

BORIS DOI:

10.7892/boris.148103

URI:

https://boris.unibe.ch/id/eprint/148103

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