Beckmann, Sven; Dettmer, Matthias S.; Caversaccio, Marco D.; Giger, Roland; Anschütz, Lukas (2020). Pleomorphic Adenoma of External Auditory Canal: Case Report of First Endoscopic Resection and Literature Review. Medicina, 56(5) MDPI 10.3390/medicina56050248
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Pleomorphic Adenoma of External Auditory Canal.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (2MB) | Preview |
Ceruminous pleomorphic adenoma is a very rare, mostly benign tumor originating from the ceruminal glands in the external auditory canal. Histologically, it is a mixed tumor with epithelial and stromal parts of different proportions, and is recognized today by the World Health Organization (WHO) as a ceruminous adenoma. Similar to the pleomorphic adenoma of salivary glands, recurrence or malignant degeneration with cellular atypia and metastasis can occur on rare occasions. Here, we describe an 87-year old female patient with a growing spherical mass in the right external auditory canal. After exclusive endoscopic tumor resection, a ceruminous pleomorphic adenoma was histologically diagnosed. Due to the absence of nuclear pleomorphism, no increased mitotic rate, no perineural invasion and no fusion transcripts of the MYB or MYBL1 gene loci, an adenoid cystic carcinoma could be excluded. The postoperative course was without any evidence of complications. A literature review identified 44 articles with 49 patients that were considered. Hearing loss and ear sensations were the most commonly reported symptoms. Most cases underwent an excision via an endaural or retroauricular approach. Recurrences were described in four patients, three of which had a malignant transformation.
Keywords: Pleomorphic adenoma; ceruminal gland tumor; ceruminous adenoma; endoscopic ear surgery; external auditory canal.
Item Type: |
Journal Article (Further Contribution) |
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Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ear, Nose and Throat Disorders (ENT) 04 Faculty of Medicine > Service Sector > Institute of Pathology |
UniBE Contributor: |
Beckmann, Sven, Dettmer, Matthias, Caversaccio, Marco, Giger, Roland, Anschütz, Lukas Peter |
Subjects: |
600 Technology > 610 Medicine & health 500 Science > 570 Life sciences; biology |
ISSN: |
1648-9144 |
Publisher: |
MDPI |
Language: |
English |
Submitter: |
Carmen Heimann |
Date Deposited: |
15 Dec 2020 15:44 |
Last Modified: |
05 Dec 2022 15:42 |
Publisher DOI: |
10.3390/medicina56050248 |
PubMed ID: |
32443830 |
BORIS DOI: |
10.7892/boris.148422 |
URI: |
https://boris.unibe.ch/id/eprint/148422 |
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