Novel therapeutics for portal hypertension and fibrosis in chronic liver disease.

Guixé Muntet, Sergi; Zhu, Chang-Peng; Xie, Wei-Fen; Gracia Sancho, Jorge (2020). Novel therapeutics for portal hypertension and fibrosis in chronic liver disease. Pharmacology & therapeutics, 215, p. 107626. Elsevier 10.1016/j.pharmthera.2020.107626

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Portal hypertension (PH) is the most common non-neoplastic complication of chronic liver disease, determining clinical complications that lead to death or liver transplantation. PH results from increased resistance to portal blood flow through the cirrhotic liver, which is due to hepatic fibrosis and microcirculatory dysfunction. The present review focuses on the pathophysiology of fibrosis and PH, describes currently used treatments, and critically discusses potential therapeutic options.

Item Type:

 Journal Article (Review Article)

Division/Institute:

 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology

UniBE Contributor:

 Guixé Muntet, Sergi, Gracia Sancho, Jorge Sergio

Subjects:

 600 Technology > 610 Medicine & health

ISSN:

 0163-7258

Publisher:

 Elsevier

Language:

 English

Submitter:

 Thi Thao Anh Pham

Date Deposited:

 09 Dec 2020 18:32

Last Modified:

 05 Dec 2022 15:42

Publisher DOI:

 10.1016/j.pharmthera.2020.107626

PubMed ID:

 32659305

Uncontrolled Keywords:

 Cirrhosis Hepatic hemodynamic Hepatic stellate cells Liver microcirculation Portal pressure

BORIS DOI:

 10.7892/boris.148516

URI:

 https://boris.unibe.ch/id/eprint/148516

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