Parvovirus 4 infection and clinical outcome in high-risk populations

Simmons, Ruth; Sharp, Colin; McClure, C Patrick; Rohrbach, Janine; Kovari, Helen; Frangou, Eleni; Simmonds, Peter; Irving, Will; Rauch, Andri; Bowness, Paul; Klenerman, Paul; Swiss HIV, Cohort Study (2012). Parvovirus 4 infection and clinical outcome in high-risk populations. Journal of infectious diseases, 205(12), pp. 1816-20. Cary, N.C.: Oxford University Press 10.1093/infdis/jis291

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Parvovirus 4 (PARV4) is a DNA virus frequently associated with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections, but its clinical significance is unknown. We studied the prevalence of PARV4 antibodies in 2 cohorts of HIV- and HCV-infected individuals (n = 469) and the correlations with disease status. We found that PARV4 infection frequently occurred in individuals exposed to bloodborne viruses (95% in HCV-HIV coinfected intravenous drug users [IDUs]). There were no correlations between PARV4 serostatus and HCV outcomes. There was, however, a significant association with early HIV-related symptoms, although because this was tightly linked to both HCV status and clinical group (IDU), the specific role of PARV4 is not yet clear.

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