High subcutaneous adipose tissue density correlates negatively with survival in patients with hepatocellular carcinoma.

von Hessen, Leona; Roumet, Marie; Maurer, Martin; Lange, Naomi; Reeves, Helen; Dufour, Jean-François; Radu, Pompilia (2021). High subcutaneous adipose tissue density correlates negatively with survival in patients with hepatocellular carcinoma. Liver international, 41(4), pp. 828-836. Wiley 10.1111/liv.14755

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BACKGROUND & AIMS

Body composition parameters have been reported to add information, which can lead to tailored treatment and prognostication for oncological patients. Data for patients with hepatocellular carcinoma (HCC) are scarce. We assessed the association between different body composition parameters and overall survival (OS) in two different newly diagnosed HCC populations.

METHODS

The area (cm2 ) and density (Hounsfield Units (HU)) of skeletal muscle (SM) and adipose tissue (subcutaneous (SAT), visceral (VAT) and intermuscular (IMAT)) were measured on computed tomography (CT) scans at the level of the third lumbar vertebra (L3) in two cohorts of patients diagnosed in different HCC stages (Bern, Switzerland n=187 and Newcastle, United Kingdom n=216). Univariate and multivariate Cox regressions analyses were used to assess the crude and adjusted association of body composition parameters with OS.

RESULTS

By univariate analysis, in both cohorts, Bern and Newcastle, high SAT density (Hazard Ratio (HR): 1.35; 1.12-1.62, p<0.001 and 1.44; 1.27-1.63, p<0.001, respectively) and high VAT density (HR: 1.38; 1.1-1.72, p=0.005 and HR: 1.53; 1.3-1.81, p<0.001, respectively) correlated negatively with survival. After model adjustment for potential baseline confounders (gender, age, diabetes, cirrhosis, MELD score, BCLC stage) in a multivariate analysis, SAT density remained associated with mortality in Bern and Newcastle (Bern: HR: 1.27; 1.04-1.57, p=0.022; Newcastle: HR: 1.23; 1.03-1.48, p=0.022) and VAT remained associated with mortality in Bern (HR: 1.31; 1.05-1.65, p=0.019).

CONCLUSIONS

Based on two HCC cohorts, our data show that high SAT density correlates negatively with OS in HCC patients.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology
04 Faculty of Medicine > Pre-clinic Human Medicine > CTU Bern

Graduate School:

Graduate School for Health Sciences (GHS)

UniBE Contributor:

Prinzessin von Hessen-Philippsthal-Barchfeld, Leona Isabella; Roumet, Marie Camille; Maurer, Martin; Lange, Franziska Naomi; Dufour, Jean-François and Radu, Iuliana-Pompilia

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1478-3231

Publisher:

Wiley

Language:

English

Submitter:

Maria de Fatima Henriques Bernardo

Date Deposited:

18 Dec 2020 18:24

Last Modified:

11 May 2021 09:13

Publisher DOI:

10.1111/liv.14755

PubMed ID:

33280219

Uncontrolled Keywords:

analytic morphomics body composition computed tomography outcome

BORIS DOI:

10.7892/boris.149136

URI:

https://boris.unibe.ch/id/eprint/149136

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