Beta-blockers in cirrhosis: Evidence-based indications and limitations.

G. Rodrigues, Susana; Mendoza, Yuly P.; Bosch, Jaime (2020). Beta-blockers in cirrhosis: Evidence-based indications and limitations. JHEP reports, 2(1), p. 100063. Elsevier 10.1016/j.jhepr.2019.12.001

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Non-selective beta-blockers (NSBBs) are the mainstay of treatment for portal hypertension in the setting of liver cirrhosis. Randomised controlled trials demonstrated their efficacy in preventing initial variceal bleeding and subsequent rebleeding. Recent evidence indicates that NSBBs could prevent liver decompensation in patients with compensated cirrhosis. Despite solid data favouring NSBB use in cirrhosis, some studies have highlighted relevant safety issues in patients with end-stage liver disease, particularly with refractory ascites and infection. This review summarises the evidence supporting current recommendations and restrictions of NSBB use in patients with cirrhosis.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine

UniBE Contributor:

Gomes Rodrigues, Susana; Mendoza Jaimes, Yuly Paulin and Bosch, Jaime

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2589-5559

Publisher:

Elsevier

Language:

English

Submitter:

Thi Thao Anh Pham

Date Deposited:

11 Jan 2021 10:06

Last Modified:

10 Mar 2021 23:32

Publisher DOI:

10.1016/j.jhepr.2019.12.001

PubMed ID:

32039404

Uncontrolled Keywords:

ACLF ACLF, acute-on-chronic liver failure AKI, acute kidney injury ALD, alcohol-related liver disease ARD, absolute risk difference AV, atrioventricular EBL, endoscopic band ligation GOV, gastroesophageal varices HRS, hepatorenal syndrome HVPG, hepatic venous pressure gradient IGV, isolated gastric varices IRR, incidence rate ratio ISMN, isosorbide mononitrate MAP, mean arterial pressure NASH, non-alcoholic steatohepatitis NNH, number needed to harm NNT, number needed to treat NR, not reported NSBBs NSBBs, non-selective beta-blockers OR, odds ratio PH, portal hypertension PHG, portal hypertensive gastropathy RCT, randomised controlled trials RR, risk ratio SBP, spontaneous bacterial peritonitis SCL, sclerotherapy TIPS, transjugular intrahepatic portosystemic shunt ascites cirrhosis portal hypertension spontaneous bacterial peritonitis varices

BORIS DOI:

10.48350/149908

URI:

https://boris.unibe.ch/id/eprint/149908

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