Offline Bi‐Frontal Anodal Transcranial Direct Current Stimulation Decreases Total Sleep Time Without Disturbing Overnight Memory Consolidation.

Frase, Lukas; Jahn, Friederike; Tsodor, Sulamith; Krone, Lukas; Selhausen, Peter; Feige, Bernd; Maier, Jonathan G.; Piosczyk, Hannah; Riemann, Dieter; Nitsche, Michael A.; Nissen, Christoph (2021). Offline Bi‐Frontal Anodal Transcranial Direct Current Stimulation Decreases Total Sleep Time Without Disturbing Overnight Memory Consolidation. Neuromodulation, 24(5), pp. 910-915. Wiley 10.1111/ner.13163

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Objectives: A proposed replay of memory traces between the hippocampus and frontal cortical brain areas during sleep is of high relevance for overnight memory consolidation. Recently, we demonstrated that bi-frontal anodal transcranial direct current stimulation (tDCS) prior to sleep increases waking EEG gamma power and decreases total sleep time during the night. It is unclear whether this effect on cortical excitability has an influence on overnight memory consolidation. We hypothesized that bi-frontal evening tDCS interferes with overnight memory consolidation with a polarity specific impairment following anodal tDCS.

Materials and methods: Nineteen healthy participants underwent a within-subject, repeated-measures protocol in the sleep laboratory with bi-frontal tDCS applied prior to sleep according to the experimental protocol (anodal, cathodal, sham stimulation). Memory tasks for declarative and procedural memory were assessed prior to tDCS and on the following morning.

Results: No deterioration of overnight memory consolidation following evening offline bi-frontal tDCS could be detected.

Conclusion(s): The application of tDCS can be considered safe regarding overnight memory consolidation and represents a promising treatment approach in conditions of decreased vigilance and arousal.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy

UniBE Contributor:

Maier, Jonathan Gabriel and Nissen, Christoph

Subjects:

100 Philosophy > 150 Psychology
600 Technology > 610 Medicine & health

ISSN:

1525-1403

Publisher:

Wiley

Language:

English

Submitter:

Ersilia Trinca

Date Deposited:

05 Jan 2021 16:52

Last Modified:

23 Jul 2021 01:31

Publisher DOI:

10.1111/ner.13163

PubMed ID:

32394544

BORIS DOI:

10.48350/150185

URI:

https://boris.unibe.ch/id/eprint/150185

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