Sigel, Erwin; Steinmann, Michael E (2012). Structure, function, and modulation of GABA(A) receptors. Journal of biological chemistry, 287(48), pp. 40224-31. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.R112.386664
Full text not available from this repository.The GABA(A) receptors are the major inhibitory neurotransmitter receptors in mammalian brain. Each isoform consists of five homologous or identical subunits surrounding a central chloride ion-selective channel gated by GABA. How many isoforms of the receptor exist is far from clear. GABA(A) receptors located in the postsynaptic membrane mediate neuronal inhibition that occurs in the millisecond time range; those located in the extrasynaptic membrane respond to ambient GABA and confer long-term inhibition. GABA(A) receptors are responsive to a wide variety of drugs, e.g. benzodiazepines, which are often used for their sedative/hypnotic and anxiolytic effects.
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine |
UniBE Contributor: |
Sigel, Erwin, Steinmann, Michael Eduard |
ISSN: |
0021-9258 |
Publisher: |
American Society for Biochemistry and Molecular Biology |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:37 |
Last Modified: |
05 Dec 2022 14:11 |
Publisher DOI: |
10.1074/jbc.R112.386664 |
PubMed ID: |
23038269 |
Web of Science ID: |
000311448800014 |
URI: |
https://boris.unibe.ch/id/eprint/15039 (FactScience: 222193) |
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