Multiple Endocrine Neoplasia Type 1 (MEN1) and the Pancreas - Diagnosis and Treatment of Functioning and Non-Functioning Pancreatic and Duodenal Neuroendocrine Neoplasia within the MEN1 Syndrome - An International Consensus Statement.

Niederle, Bruno; Selberherr, Andreas; Bartsch, Detlef; Brandi, Maria Luisa; Doherty, Gerard M; Falconi, Massimo; Goudet, Pierre; Halfdanarson, Thorvardur R; Ito, Tetsuhide; Jensen, Robert T; Larghi, Alberto; Lee, Lingaku; Oberg, Kjell; Pavel, Marianne; Perren, Aurel; Sadowski, Samira M; Tonelli, Francesco; Triponez, Frederic; Valk, Gerlof D; O'Toole, Dermot; ... (2020). Multiple Endocrine Neoplasia Type 1 (MEN1) and the Pancreas - Diagnosis and Treatment of Functioning and Non-Functioning Pancreatic and Duodenal Neuroendocrine Neoplasia within the MEN1 Syndrome - An International Consensus Statement. (In Press). Neuroendocrinology Karger 10.1159/000511791

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The better understanding of the biological behavior of MEN1 organ manifestations and the in-crease in clinical experience warrant a revision of previously published guidelines. DP-NENs are still the second most common manifestation in MEN1 and, besides NENs of the thymus, remain a leading cause of death. DP-NENs are thus of main interest in the effort to re-evaluate recommendations for their diagnosis and treatment. Especially over the last two years, more clinical experience has documented the follow-up of treated and untreated (natural-course) DP-NENs. It was the aim of the international consortium of experts in endocrinology, genetics, radiology, surgery, gastroenterology and oncology to systematically review the literature and to present a consensus statement based on the highest levels of evidence. Reviewing the literature published over the past decade, the focus was on the diagnosis of F- and NF-DP-NENs within the MEN1 syn-drome in an effort to further standardize and improve treatment and follow-up, as well as to es-tablish a "logbook" for the diagnosis and treatment of DP-NENs. This shall help further reduce complications and improve long-term treatment results in these rare tumors. The following international consensus statement builds upon the previously published guide-lines of 2001 and 2012 and attempts to supplement the recommendations issued by various na-tional and international societies.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Perren, Aurel

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0028-3835

Publisher:

Karger

Language:

English

Submitter:

Aurel Perren

Date Deposited:

19 Jan 2021 14:38

Last Modified:

19 Jan 2021 14:38

Publisher DOI:

10.1159/000511791

PubMed ID:

32971521

BORIS DOI:

10.7892/boris.150434

URI:

https://boris.unibe.ch/id/eprint/150434

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