Astrovirus-Associated Polioencephalomyelitis in an Alpaca

Küchler, Leonore; Rüfli, Isabelle; Koch, Michel C.; Hierweger, Melanie M.; Kauer, Ronja V.; Boujon, Céline L.; Hilbe, Monika; Oevermann, Anna; Zanolari, Patrik; Seuberlich, Torsten; Gurtner, Corinne (2020). Astrovirus-Associated Polioencephalomyelitis in an Alpaca. Viruses, 13(1), p. 50. Molecular Diversity Preservation International MDPI 10.3390/v13010050

[img]
Preview
Text
viruses-13-00050.pdf - Published Version
Available under License Creative Commons: Attribution (CC-BY).

Download (1MB) | Preview

An 8-year-old alpaca was admitted to the emergency service of the Clinic for Ruminantsin Bern due to a reduced general condition and progressive neurological signs. Despite supportive treatment, its condition deteriorated and the animal had to be euthanized. Histopathological analysis revealed a severe non-suppurative polioencephalomyelitis with neuronal necrosis, most likely of viral origin. We detected abundant neuronal labelling with antibodies directed against two different epitopes of Bovine Astrovirus CH13/NeuroS1 (BoAstV-CH13/NeuroS1), which is a common viral agent associated with non-suppurative encephalitis in Swiss cattle. These findings were further verified by detection of viral RNA by use of in-situ hybridization and real-time RT-PCR. Next generation sequencing revealed that the detected virus genome had a pairwise identity of 98.9% to the genome of BoAstV-CH13/NeuroS1. To our knowledge, this is the first report of an astrovirus associated
polioencephalomyelitis in an alpaca. These results point to the possibility of an interspecies
transmission of BoAstV-CH13/NeuroS1.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV)
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Clinic for Ruminants
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Veterinary Public Health Institute
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Experimental Clinical Research
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Animal Pathology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Center for Fish and Wildlife Health (FIWI)

UniBE Contributor:

Küchler, Leonore; Rüfli, Isabelle Christina; Koch, Michel Christoph; Hierweger, Melanie Michaela; Kauer, Ronja Veronique; Oevermann, Anna; Zanolari, Patrik; Seuberlich, Torsten and Gurtner, Corinne

Subjects:

600 Technology > 630 Agriculture
500 Science > 590 Animals (Zoology)
600 Technology > 610 Medicine & health

ISSN:

1999-4915

Publisher:

Molecular Diversity Preservation International MDPI

Language:

English

Submitter:

Nathalie Viviane Zollinger

Date Deposited:

05 Jan 2021 11:40

Last Modified:

07 Mar 2021 22:03

Publisher DOI:

10.3390/v13010050

PubMed ID:

33396858

BORIS DOI:

10.48350/150502

URI:

https://boris.unibe.ch/id/eprint/150502

Actions (login required)

Edit item Edit item
Provide Feedback