Calcium cytotoxicity sensitizes prostate cancer cells to standard-of-care treatments for locally advanced tumors.

Alaimo, Alessandro; Lorenzoni, Marco; Ambrosino, Paolo; Bertossi, Arianna; Bisio, Alessandra; Macchia, Alice; Zoni, Eugenio; Genovesi, Sacha; Cambuli, Francesco; Foletto, Veronica; De Felice, Dario; Soldovieri, Maria Virginia; Mosca, Ilaria; Gandolfi, Francesco; Brunelli, Matteo; Petris, Gianluca; Cereseto, Anna; Villarroel, Alvaro; Thalmann, George; Carbone, Francesco Giuseppe; ... (2020). Calcium cytotoxicity sensitizes prostate cancer cells to standard-of-care treatments for locally advanced tumors. Cell death & disease, 11(12), p. 1039. Nature Publishing Group 10.1038/s41419-020-03256-5

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Therapy resistance is a major roadblock in oncology. Exacerbation of molecular dysfunctions typical of cancer cells have proven effective in twisting oncogenic mechanisms to lethal conditions, thus offering new therapeutic avenues for cancer treatment. Here, we demonstrate that selective agonists of Transient Receptor Potential cation channel subfamily M member 8 (TRPM8), a cation channel characteristic of the prostate epithelium frequently overexpressed in advanced stage III/IV prostate cancers (PCa), sensitize therapy refractory models of PCa to radio, chemo or hormonal treatment. Overall, our study demonstrates that pharmacological-induced Ca2+ cytotoxicity is an actionable strategy to sensitize cancer cells to standard therapies.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Urologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Urologie

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Urology

UniBE Contributor:

Zoni, Eugenio; Thalmann, George and Kruithof-de Julio, Marianna

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2041-4889

Publisher:

Nature Publishing Group

Language:

English

Submitter:

Jeannine Wiemann

Date Deposited:

21 Jan 2021 11:50

Last Modified:

12 Mar 2021 08:03

Publisher DOI:

10.1038/s41419-020-03256-5

PubMed ID:

33288740

BORIS DOI:

10.48350/150552

URI:

https://boris.unibe.ch/id/eprint/150552

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