04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Urologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Urologie

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Number of items at this level: 57.

2020

Minoli, Martina; Kiener, Mirjam; Thalmann, George N.; Kruithof-de Julio, Marianna; Seiler, Roland (2020). Evolution of Urothelial Bladder Cancer in the Context of Molecular Classifications. International journal of molecular sciences, 21(16) MDPI 10.3390/ijms21165670

Bonollo, Francesco; Thalmann, George; Kruithof-de Julio, Marianna; Karkampouna, Sofia (2020). The Role of Cancer-Associated Fibroblasts in Prostate Cancer Tumorigenesis. Cancers, 12(7) MDPI AG 10.3390/cancers12071887

Rodrigues Sousa, Elisa; Zoni, Eugenio; Karkampouna, Sofia; La Manna, Federico; Gray, Peter C.; De Menna, Marta; Kruithof-de Julio, Marianna (2020). A Multidisciplinary Review of the Roles of Cripto in the Scientific Literature Through a Bibliometric Analysis of its Biological Roles. Cancers, 12(6) MDPI AG 10.3390/cancers12061480

Chen, Lanpeng; Boleslaw Olszewski, Maciej; Kruithof-de Julio, Marianna; Snaar-Jagalska, B Ewa (2020). Zebrafish Microenvironment Elevates EMT and CSC-Like Phenotype of Engrafted Prostate Cancer Cells. Cells, 9(4) MDPI 10.3390/cells9040797

Chen, Lanpeng; De Menna, Marta; Groenewoud, Arwin; Thalmann, George N.; Kruithof-de Julio, Marianna; Snaar-Jagalska, B Ewa (2020). A NF-ĸB-Activin A signaling axis enhances prostate cancer metastasis. Oncogene, 39(8), pp. 1634-1651. Springer Nature 10.1038/s41388-019-1103-0

La Manna, Federico; De Menna, Marta; Patel, Nikhil; Karkampouna, Sofia; De Filippo, Maria; Klima, Irena; Kloen, Peter; Beimers, Lijkele; Thalmann, George N.; Pelger, Rob C M; Jacinto, Estela; Kruithof-de Julio, Marianna (2020). Dual-mTOR Inhibitor Rapalink-1 Reduces Prostate Cancer Patient-Derived Xenograft Growth and Alters Tumor Heterogeneity. Frontiers in oncology, 10(1012), p. 1012. Frontiers Research Foundation 10.3389/fonc.2020.01012

2019

Gavini, Jacopo; Dommann, Noëlle; Jakob, Manuel O.; Keogh, Adrian; Bouchez, Laure C; Karkampouna, Sofia; Kruithof-de Julio, Marianna; Medova, Michaela; Zimmer, Yitzhak; Schläfli, Anna M; Tschan, Mario P.; Candinas, Daniel; Stroka, Deborah; Banz, Vanessa (2019). Verteporfin-induced lysosomal compartment dysregulation potentiates the effect of sorafenib in hepatocellular carcinoma. Cell death & disease, 10(10), p. 749. Springer Nature 10.1038/s41419-019-1989-z

Zoni, E.; Bovet, C.; Spahn, M.; Thalmann, G.; Kruithof-de Julio, M. (4 September 2019). LC-MS metabolic profiling of plasma from patient with high prostate cancer risk (Unpublished). In: 75. Jahresversammlung SGU. Zürich. 04. - 06.09.2019.

Clavica, Francesco; Roth, Joy; Schneider, Marc Philipp; Civet, Yoan; Burkhard, Fiona; Perriard, Yves; Obrist, Dominik (3 September 2019). Urine-Contactless Device to Empty Bladders: an Ex-Vivo Proof-of-Concept Study in Porcine Bladders (In Press). In: 49th International Continence Society Annual Meeting. Gothenburg, Sweden.

Kiener, Mirjam; Chen, Lanpeng; Krebs, Markus; Grosjean, Joël; Klima, Irena; Kalogirou, Charis; Riedmiller, Hubertus; Kneitz, Burkhard; Thalmann, George; Snaar-Jagalska, Ewa; Spahn, Martin; Kruithof-de Julio, Marianna; Zoni, Eugenio (2019). miR-221-5p regulates proliferation and migration in human prostate cancer cells and reduces tumor growth in vivo. BMC cancer, 19(1), p. 627. BioMed Central 10.1186/s12885-019-5819-6

Panzetta, V; Pugliese, M G; Musella, I; De Menna, Marta; Netti, P A; Fusco, S (2019). A BIOPHYSICAL ANALYSIS TO ASSESS X-RAY SENSITIVITY OF HEALTHY AND TUMOUR CELLS. Radiation protection dosimetry, 183(1-2), pp. 116-120. Oxford University Press 10.1093/rpd/ncy303

Zoni, Eugenio; Astrologo, Letizia; Ng, Kiu Yan Charlotte; Piscuoglio, Salvatore; Melsen, Janine; Grosjean, Joël; Klima, Irena; Chen, Lanpeng; Snaar-Jagalska, Ewa B; Flanagan, Kenneth; van der Pluijm, Gabri; Kloen, Peter; Cecchini, Marco G; Kruithof-de Julio, Marianna; Thalmann, George (2019). Therapeutic targeting of CD146/MCAM reduces bone metastasis in prostate cancer. Molecular cancer research, 17(5), pp. 1049-1062. American Association for Cancer Research AACR 10.1158/1541-7786.MCR-18-1220

Hashemi Gheinani, Ali; Burkhard, F.; Rehrauer, H.; Aquino Fournier, C.; Rémi, B.; Monastyrskaya, K. (15 March 2019). Molecular characterization of bladder pain syndrome identifies functional mRNA-microRNA regulatory modules. European Urology Supplements, 18(1), e718-e718. Elsevier 10.1016/S1569-9056(19)30527-5

Küffer, M.; Besic, M.; Hashemi Gheinani, A.; Vassella, E.; Schneider, M.; Burkhard, F. C.; Monastyrskaya, K. (15 March 2019). Urinary miRNA profiles discriminate between BPO patients and healthy controls. European Urology Supplements, 18(1), e715-e715. Elsevier 10.1016/S1569-9056(19)30525-1

Monastyrskaya, K.; Besic, M.; Hashemi Gheinani, A.; Burkhard, F. C. (15 March 2019). Dysregulation of phospholamban and beta 3-adrenergic receptor expression might lead to bladder detrusor overactivity via SERCA inhibition. European Urology Supplements, 18(1), e711-e711. Elsevier 10.1016/S1569-9056(19)30521-4

Borgström, A.; Kiener, M.; Kappel, S.; Hauert, B.; Delalande, C.; Zoni, E.; Reymond, J.; Thalmann, G. N.; Peinelt, C.; Kruithof-de Julio, M. (15 March 2019). Investigation of TRPM4 and store-operated calcium entry in prostate cancer cell systems and a primary prostate cancer stem cell model. European Urology Supplements, 18(1), e342-e342. Elsevier https://doi.org/10.1016/S1569-9056(19)30254-4

La Manna, F.; Staender, L.; Gray, P. C.; Zoni, E.; Karkampouna, S.; Thalmann, G. N.; Kruithof-de Julio, M. (15 March 2019). Cripto blockade reduces prostate cancer reactivity to microenvironment and metastatic potential. European Urology Supplements, 18(1), e1156-e1156. Elsevier 10.1016/S1569-9056(19)30833-4

La Manna, Federico; Karkampouna, Sofia; Zoni, Eugenio; De Menna, Marta; Hensel, Janine; Thalmann, George; Kruithof-de Julio, Marianna (2019). Metastases in Prostate Cancer. Cold Spring Harbor perspectives in medicine, 9(3) Cold Spring Harbor Laboratory Press 10.1101/cshperspect.a033688

Karkampouna, Sofia; Grosjean, Joël; Klima, Irena; Genitsch, Vera; Sboner, A.; K. Y. Ng, C.; De Filippo, M.R.; Piscuoglio, S.; Spahn, M.; Rubin, Mark Andrew; Thalmann, G.N.; Kruithof-de Julio, Marianna (2019). Establishment of an androgen-sensitive patient derived xenograft model of prostate cancer. European Urology Supplements, 18(1), e1154. Elsevier 10.1016/S1569-9056(19)30831-0

Zoni, Eugenio; Minoli, Martina; Bovet, Cédric; Wehrhan, Anne; Piscuoglio, Salvatore; Ng, Kiu Yan; Gray, Peter C.; Spahn, Martin; Thalmann, George N.; Kruithof-de Julio, Marianna (2019). Preoperative plasma fatty acid metabolites inform risk of prostate cancer progression and may be used for personalized patient stratification. BMC cancer, 19(1), p. 1216. BioMed Central 10.1186/s12885-019-6418-2

De Menna, Marta; Rodrigues Sousa, Elisa; La Manna, Federico; Zeinali, Soheila; Guenat, Olivier; Kruithof-de Julio, Marianna; Thalmann, George N. (2019). Microvasculature on chip: Cancer cells extravasation in vitro modeling. The journal of urology, 201(Suppl 4), e1170-e1171. American Urological Association 10.1097/01.JU.0000557420.34464.34

Krentel, F.; Singer, F.; Gibb, E. A.; Liu, Y.; Davicioni, E.; Kruithof-de Julio, M.; Seiler, R. (2019). Medikamentöse Tumortherapie für das muskelinvasive Blasenkarzinom basierend auf dessen genetischen Profil. Der Urologe, 58(Suppl 1), S100-S100. Springer

Borgström, A.; Kiener, M.; Kappel, S.; Hauert, B.; Delalande, C.; Zoni, E.; Reymond, J.-L.; Thalmann, G. N.; Peinelt, C.; Kruithof-de Julio, M. (2019). Investigation of TRPM4 and store-operated calcium entry in prostate cancer cell systems and a primary prostate cancer stem cell model. Der Urologe, 58(Suppl 1), S42-S42. Springer https://doi.org/10.1007/s00120-019-1018-y

Kiener, M.; Chen, L.; Krebs, M.; Grosjean, J.; Klima, I.; Herreiner, P.; Kalogiro, C.; Riedmiller, H.; Kneitz, B.; Thalmann, G. N.; Snaar-Jagalska, E.; Spahn, E.; Kruithof-de Julio, M.; Zoni, E. (2019). miR-221-5p decreases proliferation and migration in human prostate cancer cells and reduces tumor burden in vivo. Der Urologe, 58(Suppl 1), S40-S40. Springer

Kiener, M.; Karkampouna, S.; Thalmann, G. N.; Seiler, R.; Kruithof-de Julio, M. (2019). Characterisation of bladder cancer drug responses in organoids and ex vivo models. Der Urologe, 58(Suppl 1), S101-S101. Springer

2018

Hauser, Michel; Siegrist, Mark; Denzer, Alain; Saulacic, Nikola; Grosjean, Joël; Bohner, Marc; Hofstetter, Wilhelm (2018). Bisphosphonates reduce biomaterial turnover in healing of critical-size rat femoral defects. Journal of orthopaedic surgery, 26(3), p. 2309499018802487. Hong Kong University Press 10.1177/2309499018802487

Thöny, Harriet C.; Bellin, Marie-France; Comperat, Eva-Maria; Thalmann, George (2018). Vesical Imaging-Reporting and Data System (VI-RADS): Added Value for Management of Bladder Cancer Patients? European urology, 74(3), pp. 307-308. Elsevier 10.1016/j.eururo.2018.06.017

Furrer, Marc; Schneider, Marc Philipp; Löffel, Lukas M.; Burkhard, Fiona C.; Wüthrich, Patrick Yves (2018). Impact of intra-operative fluid and noradrenaline administration on early postoperative renal function after cystectomy and urinary diversion: A retrospective observational cohort study. European journal of anaesthesiology, 35(9), pp. 641-649. Lippincott Williams & Wilkins 10.1097/EJA.0000000000000808

Häberlin, Andreas; Schürch, Klaus; Niederhauser, Thomas; Sweda, Romy; Schneider, Marc Philipp; Obrist, Dominik; Burkhard, Fiona C.; Clavica, Francesco (2018). Cardiac electrophysiology catheters for electrophysiological assessments of the lower urinary tract—A proof of concept ex vivo study in viable ureters. Neurourology and urodynamics, 38(1), pp. 87-96. Wiley-Liss 10.1002/nau.23816

Koeck, Ivonne; Hashemi Gheinani, Ali; Baumgartner, Ulrich; Vassella, Erik; Bruggmann, Rémy; Burkhard, Fiona C.; Monastyrskaya, Katia (2018). Tumor Necrosis Factor-α Initiates miRNA-mRNA Signaling Cascades in Obstruction-Induced Bladder Dysfunction. The American journal of pathology, 188(8), pp. 1847-1864. Elsevier 10.1016/j.ajpath.2018.05.008

La Manna, Federico; Karkampouna, Sofia; Zoni, Eugenio; De Menna, Marta; Hensel, Janine; Thalmann, George; Kruithof-de Julio, Marianna (2018). Erratum: Metastases in Prostate Cancer. Cold Spring Harbor perspectives in medicine, 8(7) Cold Spring Harbor Laboratory Press 10.1101/cshperspect.a035568

Karkampouna, Sofia; van der Helm, Danny; Gray, Peter C; Chen, Lanpeng; Klima, Irena; Grosjean, Joël; Burgmans, Mark C; Farina-Sarasqueta, Arantza; Snaar-Jagalska, Ewa B; Keogh-Stroka, Deborah M.; Terracciano, Luigi; van Hoek, Bart; Schaapherder, Alexander F; Osanto, Susan; Thalmann, George; Verspaget, Hein W; Coenraad, Minneke J; Kruithof-de Julio, Marianna (2018). CRIPTO promotes an aggressive tumour phenotype and resistance to treatment in hepatocellular carcinoma. Journal of pathology, 245(3), pp. 297-310. Wiley 10.1002/path.5083

Hensel, Janine; Wetterwald, Antoinette; Temanni, Ramzi; Keller, Irene; Riether, Carsten; van der Pluijm, Gabri; Cecchini, Marco G; Thalmann, George N. (2018). Osteolytic cancer cells induce vascular/axon guidance processes in the bone/bone marrow stroma. OncoTarget, 9(48), pp. 28877-28896. Impact Journals LLC 10.18632/oncotarget.25608

Hashemi Gheinani, Ali; Vögeli, Mike; Baumgartner, Ulrich; Vassella, Erik; Draeger, Annette; Burkhard, Fiona C.; Monastyrskaya-Stäuber, Katia (2018). Improved isolation strategies to increase the yield and purity of human urinary exosomes for biomarker discovery. Scientific Reports, 8(1), p. 3945. Nature Publishing Group 10.1038/s41598-018-22142-x

Schneider, Marc Philipp; Löffel, Lukas M; Furrer, Marc; Burkhard, Fiona C.; Kleeb, Bettina; Curatolo, Michele; Wüthrich, Patrick Yves (2018). Can early oral prolonged-release oxycodone, with or without naloxone reduce the duration of epidural analgesia after cystectomy? A three-arm, randomized, double-blind, placebo-controlled trial. Pain, 159(3), pp. 560-567. Wolters Kluwer 10.1097/j.pain.0000000000001112

Girsberger, Stefan Alexander; Schneider, Marc Philipp; Löffel, Lukas M; Burkhard, Fiona C.; Wüthrich, Patrick Yves (2018). Effect of Thoracic Epidural Ropivacaine versus Bupivacaine on Lower Urinary Tract Function: A Randomized Clinical Trial. Anesthesiology, 128(3), pp. 511-519. Lippincott Williams & Wilkins 10.1097/ALN.0000000000001980

Zoni, Eugenio; Karkampouna, Sofia; Thalmann, George; Kruithof-de Julio, Marianna; Spahn, Martin (2018). Emerging aspects of microRNA interaction with TMPRSS2-ERG and endocrine therapy. Molecular and cellular endocrinology, 462(Pt A), pp. 9-16. Elsevier Ireland 10.1016/j.mce.2017.02.009

Hashemi Gheinani, Ali; Köck, Ivonne; Vasquez, Evalynn; Baumgartner, Ulrich; Bigger-Allen, Alexander; Sack, Bryan S; Burkhard, Fiona C.; Adam, Rosalyn M; Monastyrskaya, Katia (2018). Concordant miRNA and mRNA expression profiles in humans and mice with bladder outlet obstruction. American journal of clinical and experimental urology, 6(6), pp. 219-233. e-Century Publishing

2017

Kappel, Sven; dos Santos Marques, Ines Joao; Zoni, Eugenio; Stoklosa, Paulina Agnieszka; Peinelt, Christine; Mercader Huber, Nadia; Kruithof-de Julio, Marianna; Borgström, Anna (2017). Store-Operated Ca2+ Entry as a Prostate Cancer Biomarker — a Riddle with Perspectives. Current Molecular Biology Reports, 3(4), pp. 208-217. Springer 10.1007/s40610-017-0072-8

Vasquez, Evalynn; Cristofaro, Vivian; Lukianov, Stefan; Burkhard, Fiona C.; Hashemi Gheinani, Ali; Monastyrskaya-Stäuber, Katia; Bielenberg, Diane R; Sullivan, Maryrose P; Adam, Rosalyn M (2017). Deletion of neuropilin 2 enhances detrusor contractility following bladder outlet obstruction. JCI insight, 2(3), e90617. JCI Insight 10.1172/jci.insight.90617

Hashemi Gheinani, Ali; Kiss, Bernhard; Moltzahn, Felix Roman; Keller, Irene; Bruggmann, Rémy; Rehrauer, Hubert; Fournier, Catharine Aquino; Burkhard, Fiona C.; Monastyrskaya-Stäuber, Katia (2017). Characterization of miRNA-regulated networks, hubs of signaling, and biomarkers in obstruction-induced bladder dysfunction. JCI insight, 2(2), e89560. JCI Insight 10.1172/jci.insight.89560

Astrologo, Letizia; Zoni, Eugenio; Karkampouna, Sofia; Gray, Peter C; Klima, Irena; Grosjean, Joël; Goumans, Marie J; Hawinkels, Lukas J A C; van der Pluijm, Gabri; Spahn, Martin; Thalmann, George; Ten Dijke, Peter; Kruithof-de Julio, Marianna (2017). ALK1Fc Suppresses the Human Prostate Cancer Growth in in Vitro and in Vivo Preclinical Models. Frontiers in cell and developmental biology, 5(104), p. 104. Frontiers 10.3389/fcell.2017.00104

2016

Genitsch Gratwohl, Vera; Zlobec, Inti; Fleischmann, Achim; Thalmann, George (2016). MUC1 in lymph node metastases independently predicts survival in advanced prostate cancer patients. Prostate Cancer Prostatic Diseases, 19(3), pp. 242-247. Springer 10.1038/pcan.2016.11

Hensel, Janine; Thalmann, George (2016). Biology of Bone Metastases in Prostate Cancer. Urology, 92, pp. 6-13. Elsevier 10.1016/j.urology.2015.12.039

Köck, Ivonne; Burkhard, Fiona C.; Monastyrskaya-Stäuber, Katia (2016). Activation of common signaling pathways during remodeling of the heart and the bladder. Biochemical pharmacology, 102, pp. 7-19. Elsevier 10.1016/j.bcp.2015.09.012

2015

Tschui, Joëlle; Vassella, Erik; Bandi Hess, Nora; Baumgartner, Ulrich; Genitsch Gratwohl, Vera; Rotzer, Diana; Seiler, Roland; Thalmann, George; Fleischmann, Achim (2015). Morphological and molecular characteristics of HER2 amplified urothelial bladder cancer. Virchows Archiv, 466(6), pp. 703-710. Springer 10.1007/s00428-015-1729-4

Hashemi Gheinani, Ali; Burkhard, Fiona C.; Rehrauer, Hubert; Aquino Fournier, Catharine; Monastyrskaya-Stäuber, Katia (2015). MicroRNA miR-199a-5p regulates smooth muscle cell proliferation and morphology by targeting Wnt2 signaling pathway. Journal of biological chemistry, 290(11), pp. 7067-7086. American Society for Biochemistry and Molecular Biology 10.1074/jbc.M114.618694

Wetterauer, Christian; Vlajnic, Tatjana; Schüler, Julia; Gsponer, Joel R; Thalmann, George; Cecchini, Marco Giovanni; Schneider, Julia; Zellweger, Tobias; Püschel, Heike; Bachmann, Alexander; Ruiz, Christian; Dirnhofer, Stephan; Bubendorf, Lukas; Rentsch, Cyrill Achim (2015). Early development of human lymphomas in a prostate cancer xenograft program using triple knock-out immunocompromised mice. Prostate, 75(6), pp. 585-592. Wiley-Blackwell 10.1002/pros.22939

2014

Fleischmann, Achim; Saramäki, Outi R; Zlobec, Inti; Rotzer, Diana; Genitsch Gratwohl, Vera; Seiler, Roland; Visakorpi, Tapio; Thalmann, George (2014). Prevalence and prognostic significance of TMPRSS2-ERG gene fusion in lymph node positive prostate cancers. Prostate, 74(16), pp. 1647-1654. Wiley-Blackwell 10.1002/pros.22882

Oezdemir, Berna; Hensel, Janine; Secondini, Chiara; Wetterwald, Antoinette; Schwaninger, Ruth; Fleischmann, Achim; Raffelsberger, Wolfgang; Poch, Olivier; Delorenzi, Mauro; Temanni, Ramzi; Mills, Ian G; van der Pluijm, Gabri; Thalmann, George; Cecchini, Marco Giovanni (2014). The molecular signature of the stroma response in prostate cancer-induced osteoblastic bone metastasis highlights expansion of hematopoietic and prostate epithelial stem cell niches. PLoS ONE, 9(12), e114530. Public Library of Science 10.1371/journal.pone.0114530

2013

Ricci, Estelle; Mattei, Eve; Dumontet, Charles; Eaton, Colby L.; Hamdy, Freddy; van der Pluije, Gabri; Cecchini, Marco Giovanni; Thalmann, George; Clezardin, Philippe; Colombel, Marc (2013). Increased expression of putative cancer stem cell markers in the bone marrow of prostate cancer patients is associated with bone metastasis progression. Prostate, 73(16), pp. 1738-1746. Wiley-Blackwell 10.1002/pros.22689

Monastyrskaya, Katia; Babiychuk, Eduard B.; Draeger, Annette; Burkhard, Fiona C. (2013). Down-Regulation of Annexin A1 in the Urothelium Decreases Cell Survival After Bacterial Toxin Exposure. Journal of urology, 190(1), pp. 325-333. Elsevier 10.1016/j.juro.2013.01.088

Fleischmann, Achim; Seiler, Roland; Zlobec, Inti; Visakorpi, Tapio; Thalmann, George (April 2013). TMPRSS2-ERG Gene Fusion: Frequency and Prognostic Significance in Prostate Cancer Patients with Positive Lymph Nodes. Journal of urology, 189(4), E84-E85. Elsevier

Hashemi Gheinani, Ali; Burkhard, Fiona C.; Monastyrskaya, Katia (2013). Deciphering microRNA code in pain and inflammation: lessons from bladder pain syndrome. Cellular and molecular life sciences, 70(20), pp. 3773-3789. Springer Basel 10.1007/s00018-013-1275-7

Le Magnen, Clémentine; Bubendorf, Lukas; Rentsch, Cyrill A.; Mengus, Chantal; Gsponer, Joel; Zellweger, Tobias; Rieken, Malte; Thalmann, George N.; Cecchini, Marco G.; Germann, Markus; Bachmann, Alexander; Wyler, Stephen; Heberer, Michael; Spagnoli, Giulio C. (2013). Characterization and Clinical Relevance of ALDHbright Populations in Prostate Cancer. Clinical cancer research, 19(19), pp. 5361-5371. American Association for Cancer Research 10.1158/1078-0432.CCR-12-2857

2006

Gazdhar, Amiq; Bilici, Murat; Pierog, Jaroslaw; Ayuni, Erick L; Gugger, Mathias; Wetterwald, Antoinette; Cecchini, Marco; Schmid, Ralph Alexander (2006). In vivo electroporation and ubiquitin promoter--a protocol for sustained gene expression in the lung. Journal of gene medicine, 8(7), pp. 910-8. Chichester: Wiley 10.1002/jgm.911

Rentsch, Cyrill A; Cecchini, Marco G; Schwaninger, Ruth; Germann, Markus; Markwalder, Regula; Heller, Manfred; van der Pluijm, Gabri; Thalmann, George N; Wetterwald, Antoinette (2006). Differential expression of TGFbeta-stimulated clone 22 in normal prostate and prostate cancer. International journal of cancer, 118(4), pp. 899-906. Malden, Mass.: Wiley-Blackwell 10.1002/ijc.21449

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