Mental health and its associations with glucose-lowering medication in women with gestational diabetes mellitus. A prospective clinical cohort study.

Gilbert, Leah; Nikolaou, Argyro; Quansah, Dan Yedu; Rossel, Jean-Benoît; Horsch, Antje; Puder, Jardena J (2021). Mental health and its associations with glucose-lowering medication in women with gestational diabetes mellitus. A prospective clinical cohort study. Psychoneuroendocrinology, 124, p. 105095. Elsevier 10.1016/j.psyneuen.2020.105095

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AIMS

Mental health symptoms are frequent in women with gestational diabetes mellitus (GDM) and may influence glycemic control. We therefore investigated if mental health symptoms (high depression and low well-being scores) predicted a need for glucose-lowering medication and if this use of medication influenced the trajectory of mental health during pregnancy and in the postpartum period.

METHODS

We included 341 pregnant women from a cohort of GDM women in a Swiss University Hospital. The World Health Organization Well-being Index-Five was collected at the first and last GDM and at the postpartum clinical visits and the Edinburgh Postnatal Depression Scale at the first GDM and the postpartum clinical visits. Medication intake was extracted from participants' medical records. We conducted linear and logistic regressions with depression as an interaction factor.

RESULTS

Mental health symptoms did not predict a need for medication (all p ≥ 0.29). Mental health improved over time (both p ≤ 0.001) and use of medication did not predict this change (all p ≥ 0.40). In women with symptoms of depression, medication was associated with less improvement in well-being at the postpartum clinical visit (p for interaction=0.013).

CONCLUSIONS

Mental health and glucose-lowering medication did not influence each other in an unfavourable way in this cohort of women with GDM.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > CTU Bern

UniBE Contributor:

Rossel, Jean-Benoît

ISSN:

0306-4530

Publisher:

Elsevier

Funders:

[4] Swiss National Science Foundation

Language:

English

Submitter:

Doris Kopp Heim

Date Deposited:

05 Jan 2021 11:31

Last Modified:

13 Mar 2021 20:03

Publisher DOI:

10.1016/j.psyneuen.2020.105095

PubMed ID:

33321330

Uncontrolled Keywords:

Depression Insulin Metformin Postpartum Pregnancy Well-being

BORIS DOI:

10.48350/150693

URI:

https://boris.unibe.ch/id/eprint/150693

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