The Role of Autoantibodies in Arrhythmogenesis.

Li, Jin (2021). The Role of Autoantibodies in Arrhythmogenesis. Current cardiology reports, 23(1), p. 3. Springer 10.1007/s11886-020-01430-x

[img]
Preview
Text
11886_2020_Article_1430.pdf - Published Version
Available under License Creative Commons: Attribution (CC-BY).

Download (893kB) | Preview

PURPOSE OF REVIEW

The role of autoantibodies in arrhythmogenesis has been the subject of research in recent times. This review focuses on the rapidly expanding field of autoantibody-mediated cardiac arrhythmias.

RECENT FINDINGS

Since the discovery of cardiac autoantibodies more than three decades ago, a great deal of effort has been devoted to understanding their contribution to arrhythmias. Different cardiac receptors and ion channels were identified as targets for autoantibodies, the binding of which either initiates a signaling cascade or serves as a biomarker of underlying remodeling process. Consequently, the wide spectrum of heart rhythm disturbances may emerge, ranging from atrial to ventricular arrhythmias as well as conduction diseases, irrespective of concomitant structural heart disease or manifest autoimmune disorder. The time has come to acknowledge autoimmune cardiac arrhythmias as a distinct disease entity. Establishing the autoantibody profile of patients will help to develop novel treatment approaches for patients.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine

UniBE Contributor:

Li, Jin

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1523-3782

Publisher:

Springer

Language:

English

Submitter:

Barbara Järmann-Bangerter

Date Deposited:

21 Jan 2021 14:26

Last Modified:

14 Mar 2021 15:56

Publisher DOI:

10.1007/s11886-020-01430-x

PubMed ID:

33241446

Uncontrolled Keywords:

Atrial fibrillation Autoantibodies Autoimmunity Cardiac arrhythmias Cardiac conduction disease Ventricular arrhythmia

BORIS DOI:

10.48350/150896

URI:

https://boris.unibe.ch/id/eprint/150896

Actions (login required)

Edit item Edit item
Provide Feedback