Cardiac Graft Assessment in the Era of Machine Perfusion: Current and Future Biomarkers.

Bona, Martina; Wyss, Rahel K.; Arnold, Maria; Méndez-Carmona, Natalia; Sanz, Maria N.; Günsch, Dominik; Barile, Lucio; Carrel, Thierry P.; Longnus, Sarah L. (2021). Cardiac Graft Assessment in the Era of Machine Perfusion: Current and Future Biomarkers. Journal of the American Heart Association, 10(4), e018966. American Heart Association 10.1161/JAHA.120.018966

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Heart transplantation remains the treatment of reference for patients experiencing end-stage heart failure; unfortunately, graft availability through conventional donation after brain death is insufficient to meet the demand. Use of extended-criteria donors or donation after circulatory death has emerged to increase organ availability; however, clinical protocols require optimization to limit or prevent damage in hearts possessing greater susceptibility to injury than conventional grafts. The emergence of cardiac ex situ machine perfusion not only facilitates the use of extended-criteria donor and donation after circulatory death hearts through the avoidance of potentially damaging ischemia during graft storage and transport, it also opens the door to multiple opportunities for more sensitive monitoring of graft quality. With this review, we aim to bring together the current knowledge of biomarkers that hold particular promise for cardiac graft evaluation to improve precision and reliability in the identification of hearts for transplantation, thereby facilitating the safe increase in graft availability. Information about the utility of potential biomarkers was categorized into 5 themes: (1) functional, (2) metabolic, (3) hormone/prohormone, (4) cellular damage/death, and (5) inflammatory markers. Several promising biomarkers are identified, and recommendations for potential improvements to current clinical protocols are provided.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiovascular Surgery
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Herz- und Gefässchirurgie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Herz- und Gefässchirurgie

04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)

UniBE Contributor:

Bona, Martina; Wyss, Rahel Kathrin; Arnold, Maria Regula; Méndez Carmona, Natalia; Sanz-Garcia, Maria Nieves; Günsch, Dominik; Carrel, Thierry and Henning Longnus, Sarah

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2047-9980

Publisher:

American Heart Association

Language:

English

Submitter:

Maria de Fatima Henriques Bernardo

Date Deposited:

15 Feb 2021 17:19

Last Modified:

18 Feb 2021 01:35

Publisher DOI:

10.1161/JAHA.120.018966

PubMed ID:

33522248

Uncontrolled Keywords:

biomarkers donation after circulatory death ex situ heart perfusion extended‐criteria heart donors heart transplantation

BORIS DOI:

10.48350/151788

URI:

https://boris.unibe.ch/id/eprint/151788

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