Inflammatory Chemokines in Atherosclerosis

Gencer, Selin; Evans, Bryce R.; van der Vorst, Emiel P.C.; Döring, Yvonne; Weber, Christian (2021). Inflammatory Chemokines in Atherosclerosis. Cells, 10(2) MDPI 10.3390/cells10020226

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Atherosclerosis is a long-term, chronic inflammatory disease of the vessel wall leading to the formation of occlusive or rupture-prone lesions in large arteries. Complications of atherosclerosis can become severe and lead to cardiovascular diseases (CVD) with lethal consequences. During the last three decades, chemokines and their receptors earned great attention in the research of atherosclerosis as they play a key role in development and progression of atherosclerotic lesions. They orchestrate activation, recruitment, and infiltration of immune cells and subsequent phenotypic changes, e.g., increased uptake of oxidized low-density lipoprotein (oxLDL) by macrophages, promoting the development of foam cells, a key feature developing plaques. In addition, chemokines and their receptors maintain homing of adaptive immune cells but also drive pro-atherosclerotic leukocyte responses. Recently, specific targeting, e.g., by applying cell specific knock out models have shed new light on their functions in chronic vascular inflammation. This article reviews recent findings on the role of immunomodulatory chemokines in the development of atherosclerosis and their potential for targeting.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Angiology

UniBE Contributor:

Evans, Bryce Ridley and Döring, Yvonne

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2073-4409

Publisher:

MDPI

Language:

English

Submitter:

Rebecca Scheidegger

Date Deposited:

16 Feb 2021 14:18

Last Modified:

13 Mar 2021 19:58

Publisher DOI:

10.3390/cells10020226

PubMed ID:

33503867

BORIS DOI:

10.48350/152038

URI:

https://boris.unibe.ch/id/eprint/152038

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