Johnson, Caroline H; Patterson, Andrew D; Idle, Jeffrey R; Gonzalez, Frank J (2012). Xenobiotic metabolomics: major impact on the metabolome. Annual review of pharmacology and toxicology, 52, pp. 37-56. Palo Alto, Calif.: Annual Reviews Inc. 10.1146/annurev-pharmtox-010611-134748
Full text not available from this repository.Xenobiotics are encountered by humans on a daily basis and include drugs, environmental pollutants, cosmetics, and even components of the diet. These chemicals undergo metabolism and detoxication to produce numerous metabolites, some of which have the potential to cause unintended effects such as toxicity. They can also block the action of enzymes or receptors used for endogenous metabolism or affect the efficacy and/or bioavailability of a coadministered drug. Therefore, it is essential to determine the full metabolic effects that these chemicals have on the body. Metabolomics, the comprehensive analysis of small molecules in a biofluid, can reveal biologically relevant perturbations that result from xenobiotic exposure. This review discusses the impact that genetic, environmental, and gut microflora variation has on the metabolome, and how these variables may interact, positively and negatively, with xenobiotic metabolism.
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology |
UniBE Contributor: |
Idle, Jeffrey |
ISSN: |
0362-1642 |
Publisher: |
Annual Reviews Inc. |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:38 |
Last Modified: |
05 Dec 2022 14:11 |
Publisher DOI: |
10.1146/annurev-pharmtox-010611-134748 |
PubMed ID: |
21819238 |
Web of Science ID: |
000301839600003 |
URI: |
https://boris.unibe.ch/id/eprint/15231 (FactScience: 222523) |
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