Xenobiotic metabolomics: major impact on the metabolome

Johnson, Caroline H; Patterson, Andrew D; Idle, Jeffrey R; Gonzalez, Frank J (2012). Xenobiotic metabolomics: major impact on the metabolome. Annual review of pharmacology and toxicology, 52, pp. 37-56. Palo Alto, Calif.: Annual Reviews Inc. 10.1146/annurev-pharmtox-010611-134748

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Xenobiotics are encountered by humans on a daily basis and include drugs, environmental pollutants, cosmetics, and even components of the diet. These chemicals undergo metabolism and detoxication to produce numerous metabolites, some of which have the potential to cause unintended effects such as toxicity. They can also block the action of enzymes or receptors used for endogenous metabolism or affect the efficacy and/or bioavailability of a coadministered drug. Therefore, it is essential to determine the full metabolic effects that these chemicals have on the body. Metabolomics, the comprehensive analysis of small molecules in a biofluid, can reveal biologically relevant perturbations that result from xenobiotic exposure. This review discusses the impact that genetic, environmental, and gut microflora variation has on the metabolome, and how these variables may interact, positively and negatively, with xenobiotic metabolism.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology

UniBE Contributor:

Idle, Jeffrey

ISSN:

0362-1642

Publisher:

Annual Reviews Inc.

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:38

Last Modified:

17 Mar 2015 21:30

Publisher DOI:

10.1146/annurev-pharmtox-010611-134748

PubMed ID:

21819238

Web of Science ID:

000301839600003

URI:

https://boris.unibe.ch/id/eprint/15231 (FactScience: 222523)

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