Retrospective analysis of adverse drug reactions leading to short-term emergency hospital readmission.

Banholzer, Sarah; Dunkelmann, Lea; Haschke, Manuel; Derungs, Adrian; Exadaktylos, Aristomenis; Krähenbühl, Stephan; Liakoni, Evangelia (2021). Retrospective analysis of adverse drug reactions leading to short-term emergency hospital readmission. Swiss medical weekly, 151, w20400. EMH Media 10.4414/smw.2021.20400

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AIMS OF THE STUDY

Adverse drug reactions (ADRs) are an important cause of hospital admissions. Insufficient data are available about the frequency and characteristics of ADR-related emergency readmissions in Switzerland. The aim of this retrospective study was to characterise ADRs related to short-term emergency readmissions in a large Swiss University Hospital and to assess their reporting frequency.

METHODS

Electronic records of all patients discharged from the University Hospital Bern within a 12-month period (1 January to 31 December 2012) and emergency readmission within 30 calendar days were reviewed. Case inclusion required a known ADR. Cases with intentional overdosing, lack of compliance or insufficient documentation were excluded. Identified ADR-related readmission cases were searched in the Swiss ADR reporting system to assess reporting rate.

RESULTS

There were 1294 emergency readmissions among the 4792 readmissions (14% of all admissions) within 30 days after discharge. We identified 270 cases of ADR-related readmissions, corresponding to 21% of emergency readmissions and 6% of all readmissions within 30 days. The most frequent ADRs were gastrointestinal disorders (26%), infections and infestations (19%), and nervous system disorders (10%). The most frequent drug classes leading to ADRs were antineoplastic/immunomodulating (35%) and antithrombotic agents (25%). Only 8 (3%) of the 270 cases were reported to the Swiss ADR reporting system.

CONCLUSION

ADR-related readmissions constituted a considerable part of short-term emergency readmissions. Despite being a relevant cause for rehospitalisation, only a minority of the ADRs were reported to the regulatory authorities. Strategies to prevent ADR-related readmissions and to improve reporting rates are needed.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > University Emergency Center
04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine

UniBE Contributor:

Banholzer, Sarah; Dunkelmann, Lea; Haschke, Manuel Martin; Exadaktylos, Aristomenis and Liakoni, Evangelia

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1424-3997

Publisher:

EMH Media

Language:

English

Submitter:

Christine Baumgartner

Date Deposited:

17 Feb 2021 11:42

Last Modified:

21 Feb 2021 03:02

Publisher DOI:

10.4414/smw.2021.20400

PubMed ID:

33516159

BORIS DOI:

10.48350/152359

URI:

https://boris.unibe.ch/id/eprint/152359

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