Choi, Ryan; Hulverson, Matthew A; Huang, Wenlin; Vidadala, Rama S R; Whitman, Grant R; Barrett, Lynn K; Schaefer, Deborah A; Betzer, Dana P; Riggs, Michael W; Doggett, J Stone; Hemphill, Andrew; Ortega-Mora, Luis Miguel; McCloskey, Molly C; Arnold, Samuel L M; Hackman, Robert C; Marsh, Kennan C; Lynch, James J; Freiberg, Gail M; Leroy, Bruce E; Kempf, Dale J; ... (2020). Bumped Kinase Inhibitors as therapy for apicomplexan parasitic diseases: lessons learned. International journal for parasitology, 50(5), pp. 413-422. Elsevier 10.1016/j.ijpara.2020.01.006
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Bumped Kinase Inhibitors, targeting Calcium-dependent Protein Kinase 1 in apicomplexan parasites with a glycine gatekeeper, are promising new therapeutics for apicomplexan diseases. Here we will review advances, as well as challenges and lessons learned regarding efficacy, safety, and pharmacology that have shaped our selection of pre-clinical candidates.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Parasitology |
Graduate School: |
Graduate School for Cellular and Biomedical Sciences (GCB) |
UniBE Contributor: |
Hemphill, Andrew |
Subjects: |
600 Technology > 630 Agriculture |
ISSN: |
1879-0135 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Andrew Hemphill |
Date Deposited: |
17 Feb 2021 14:47 |
Last Modified: |
05 Dec 2022 15:47 |
Publisher DOI: |
10.1016/j.ijpara.2020.01.006 |
PubMed ID: |
32224121 |
Uncontrolled Keywords: |
Apicomplexa Bumped Kinase Inhibitor Calcium-dependent Protein Kinases Cryptosporidium Gatekeeper Neospora Sarcocystis Toxoplasma |
BORIS DOI: |
10.48350/152374 |
URI: |
https://boris.unibe.ch/id/eprint/152374 |
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