Sex-Related Differences in Cardiac Channelopathies: Implications for Clinical Practice

Asatryan, Babken; Yee, Lauren; Ben-Haim, Yael; Dobner, Stephan; Servatius, Helge; Roten, Laurent; Tanner, Hildegard; Crotti, Lia; Skinner, Jonathan R.; Remme, Carol Ann; Chevalier, Philippe; Medeiros-Domingo, Argelia; Behr, Elijah R.; Reichlin, Tobias; Odening, Katja E.; Andrew D., Krahn (2021). Sex-Related Differences in Cardiac Channelopathies: Implications for Clinical Practice. Circulation, 143(7), pp. 739-752. American Heart Association 10.1161/CIRCULATIONAHA.120.048250

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Sex-related differences in prevalence, clinical presentation, and outcome of cardiac channelopathies are increasingly recognized, despite their autosomal transmission and hence equal genetic predisposition among sexes. In congenital long-QT syndrome, adult women carry a greater risk for Torsades de pointes and sudden cardiac death than do men. In contrast, Brugada syndrome is observed predominantly in adult men, with a considerably higher risk of arrhythmic sudden cardiac death in adult men than in women. In both conditions, the risk for arrhythmias varies with age. Sex-associated differences appear less evident in other cardiac channelopathies, likely a reflection of their rare(r) occurrence and our limited knowledge. In several cardiac channelopathies, sex-specific predictors of outcome have been identified. Together with genetic and environmental factors, sex hormones contribute to the sex-related disparities in cardiac channelopathies through modulation of the expression and function of cardiac ion channels. Despite these insights, essential knowledge gaps exist in the mechanistic understanding of these differences, warranting further investigation. Precise application of the available knowledge may improve the individualized care of patients with cardiac channelopathies. Promoting the reporting of sex-related phenotype and outcome parameters in clinical and experimental studies and advancing research on cardiac channelopathy animal models should translate into improved patient outcomes. This review provides a critical digest of the current evidence for sex-related differences in cardiac channelopathies and emphasizes their clinical implications and remaining gaps requiring further research.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Physiology

UniBE Contributor:

Asatryan, Babken, Dobner, Stephan, Servatius, Helge Simon (A), Roten, Laurent, Tanner, Hildegard, Reichlin, Tobias Roman, Odening, Katja Elisabeth

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1524-4539

Publisher:

American Heart Association

Language:

English

Submitter:

Babken Asatryan

Date Deposited:

28 Apr 2021 11:33

Last Modified:

29 Mar 2023 23:37

Publisher DOI:

10.1161/CIRCULATIONAHA.120.048250

PubMed ID:

33587657

BORIS DOI:

10.48350/153787

URI:

https://boris.unibe.ch/id/eprint/153787

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