Ivan, Daniela C.; Walthert, Sabrina; Berve, Kristina; Steudler, Jasmin; Locatelli, Giuseppe (2021). Dwellers and Trespassers: Mononuclear Phagocytes at the Borders of the Central Nervous System. Frontiers in immunology, 11, p. 609921. Frontiers Research Foundation 10.3389/fimmu.2020.609921
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The central nervous system (CNS) parenchyma is enclosed and protected by a multilayered system of cellular and acellular barriers, functionally separating glia and neurons from peripheral circulation and blood-borne immune cells. Populating these borders as dynamic observers, CNS-resident macrophages contribute to organ homeostasis. Upon autoimmune, traumatic or neurodegenerative inflammation, these phagocytes start playing additional roles as immune regulators contributing to disease evolution. At the same time, pathological CNS conditions drive the migration and recruitment of blood-borne monocyte-derived cells across distinct local gateways. This invasion process drastically increases border complexity and can lead to parenchymal infiltration of blood-borne phagocytes playing a direct role both in damage and in tissue repair. While recent studies and technical advancements have highlighted the extreme heterogeneity of these resident and CNS-invading cells, both the compartment-specific mechanism of invasion and the functional specification of intruding and resident cells remain unclear. This review illustrates the complexity of mononuclear phagocytes at CNS interfaces, indicating how further studies of CNS border dynamics are crucially needed to shed light on local and systemic regulation of CNS functions and dysfunctions.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute |
UniBE Contributor: |
Condeescu-Ivan, Daniela, Walthert, Sabrina, Berve, Kristina Carolin, Steudler, Jasmin Sabrina, Locatelli, Giuseppe |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1664-3224 |
Publisher: |
Frontiers Research Foundation |
Language: |
English |
Submitter: |
Andrea Stettler |
Date Deposited: |
29 Mar 2021 08:32 |
Last Modified: |
02 Mar 2023 23:34 |
Publisher DOI: |
10.3389/fimmu.2020.609921 |
PubMed ID: |
33746939 |
Uncontrolled Keywords: |
CNS inflammation cell trafficking choroid plexus macrophage cell meninges |
BORIS DOI: |
10.48350/154884 |
URI: |
https://boris.unibe.ch/id/eprint/154884 |
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