Hevia, Eva (2020). Towards a Paradigm Shift in Polar Organometallic Chemistry. CHIMIA, 74(9), pp. 681-688. Schweizerische Chemische Gesellschaft 10.2533/chimia.2020.681
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Core tools of synthetic chemistry, polar organometallic reagents (typified by organolithium and Grignard reagents) are used worldwide for constructing compounds, especially aromatic compounds, which are ubiquitous in organic chemistry and thus in numerous commodities essential to everyday life. By isolation and characterisation of key organometallic intermediates, research in our group has led to the design of polar mixed-metal reagents imbued with synergistic effects that display chemical properties and reactivity profiles far exceeding the limits of traditional single-metal reagents. These studies have improved existing, or established new fundamentally important, synthetic methodologies based on either stoichiometric or catalytic reactions. Bimetallic cooperative effects have been demonstrated in an impressive array of important bond forming reactions including deprotonative metallation, transition-metal free C-C bond formation and metal-halogen exchange to name just a few. Towards greener, more sustainable, safer chemical transformations, our group has also pioneered the use of polar organometallic reagents under air and/or with water present using biorenewable solvents such as Deep Eutectic Solvents (DES) and 2-methyl THF. Herein we summarize some of our recent efforts in this intriguing area, which we believe can make the inroads towards a step change in the practice and future scope of polar organometallic chemistry.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP) |
UniBE Contributor: |
Hevia Freire, Eva |
Subjects: |
500 Science > 570 Life sciences; biology 500 Science > 540 Chemistry |
ISSN: |
0009-4293 |
Publisher: |
Schweizerische Chemische Gesellschaft |
Funders: |
[4] Swiss National Science Foundation |
Language: |
English |
Submitter: |
Eva Hevia Freire |
Date Deposited: |
09 Apr 2021 10:21 |
Last Modified: |
05 Dec 2022 15:50 |
Publisher DOI: |
10.2533/chimia.2020.681 |
BORIS DOI: |
10.48350/155243 |
URI: |
https://boris.unibe.ch/id/eprint/155243 |
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