Azevedo, Luís; Correia, André; Almeida, Carlos F.; Molinero-Mourelle, Pedro; Correia, Maria; Del Río Highsmith, Jaime (2021). Biocompatibility and Effectiveness of a Novel, Organic Olive Oil-Based Denture Adhesive: A Multicenter Randomized and Placebo-Controlled Clinical Trial. International journal of environmental research and public health, 18(7) MDPI 10.3390/ijerph18073398
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To assess the clinical efficacy of a novel, organic olive oil-based denture adhesive and its effect on Candida albicans growth in maxillary edentulous individuals wearing complete dentures, individuals were selected from two dental schools in Portugal and Spain. Twenty-eight complete dentures were relined, following a standardized protocol. The novel product (test) was compared with a commercialized adhesive (control) and Vaseline (placebo) randomly assigned in a cross-study design. The retention resistance was measured with a gnathometer and a dynamometer. The patients related outcome evaluations with a five-point questionnaire, and the Candida albicans growth in a Sabouraud dextrose agar (SDA) medium was used to evaluate differences between the placebo and experimental product. Twenty-three participants were included. The dynamometer evaluation showed significant differences between not using a denture adhesive and using either (experimental, p = 0.03; control, p = 0.04) and no significant differences between the two adhesives (p > 0.05). In the subjective analysis, the experimental adhesive showed a significantly longer effectiveness (p = 0.001), and the control reported better results in taste (p = 0.03) and in chewing (p = 0.001). The test adhesive showed better (p < 0.001) Candida albicans growth inhibition. The experimental adhesive showed longer effectiveness than the control and the placebo with a better inhibition capacity for the growth of Candida albicans. Patients reported better abilities for speech, chewing, taste, and retirement in the control adhesive.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > School of Dental Medicine > Department of Reconstructive Dentistry and Gerodontology |
UniBE Contributor: |
Molinero Mourelle, Pedro |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1660-4601 |
Publisher: |
MDPI |
Language: |
English |
Submitter: |
Tina Lauper |
Date Deposited: |
25 May 2021 13:35 |
Last Modified: |
05 Dec 2022 15:50 |
Publisher DOI: |
10.3390/ijerph18073398 |
PubMed ID: |
33805975 |
BORIS DOI: |
10.48350/155840 |
URI: |
https://boris.unibe.ch/id/eprint/155840 |
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